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Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City

During the first phase of the COVID-19 epidemic, New York City rapidly became the epicenter of the pandemic in the United States. While molecular phylogenetic analyses have previously highlighted multiple introductions and a period of cryptic community transmission within New York City, little is kn...

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Autores principales: Dellicour, Simon, Hong, Samuel L., Vrancken, Bram, Chaillon, Antoine, Gill, Mandev S., Maurano, Matthew T., Ramaswami, Sitharam, Zappile, Paul, Marier, Christian, Harkins, Gordon W., Baele, Guy, Duerr, Ralf, Heguy, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136714/
https://www.ncbi.nlm.nih.gov/pubmed/34015049
http://dx.doi.org/10.1371/journal.ppat.1009571
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author Dellicour, Simon
Hong, Samuel L.
Vrancken, Bram
Chaillon, Antoine
Gill, Mandev S.
Maurano, Matthew T.
Ramaswami, Sitharam
Zappile, Paul
Marier, Christian
Harkins, Gordon W.
Baele, Guy
Duerr, Ralf
Heguy, Adriana
author_facet Dellicour, Simon
Hong, Samuel L.
Vrancken, Bram
Chaillon, Antoine
Gill, Mandev S.
Maurano, Matthew T.
Ramaswami, Sitharam
Zappile, Paul
Marier, Christian
Harkins, Gordon W.
Baele, Guy
Duerr, Ralf
Heguy, Adriana
author_sort Dellicour, Simon
collection PubMed
description During the first phase of the COVID-19 epidemic, New York City rapidly became the epicenter of the pandemic in the United States. While molecular phylogenetic analyses have previously highlighted multiple introductions and a period of cryptic community transmission within New York City, little is known about the circulation of SARS-CoV-2 within and among its boroughs. We here perform phylogeographic investigations to gain insights into the circulation of viral lineages during the first months of the New York City outbreak. Our analyses describe the dispersal dynamics of viral lineages at the state and city levels, illustrating that peripheral samples likely correspond to distinct dispersal events originating from the main metropolitan city areas. In line with the high prevalence recorded in this area, our results highlight the relatively important role of the borough of Queens as a transmission hub associated with higher local circulation and dispersal of viral lineages toward the surrounding boroughs.
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spelling pubmed-81367142021-06-02 Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City Dellicour, Simon Hong, Samuel L. Vrancken, Bram Chaillon, Antoine Gill, Mandev S. Maurano, Matthew T. Ramaswami, Sitharam Zappile, Paul Marier, Christian Harkins, Gordon W. Baele, Guy Duerr, Ralf Heguy, Adriana PLoS Pathog Research Article During the first phase of the COVID-19 epidemic, New York City rapidly became the epicenter of the pandemic in the United States. While molecular phylogenetic analyses have previously highlighted multiple introductions and a period of cryptic community transmission within New York City, little is known about the circulation of SARS-CoV-2 within and among its boroughs. We here perform phylogeographic investigations to gain insights into the circulation of viral lineages during the first months of the New York City outbreak. Our analyses describe the dispersal dynamics of viral lineages at the state and city levels, illustrating that peripheral samples likely correspond to distinct dispersal events originating from the main metropolitan city areas. In line with the high prevalence recorded in this area, our results highlight the relatively important role of the borough of Queens as a transmission hub associated with higher local circulation and dispersal of viral lineages toward the surrounding boroughs. Public Library of Science 2021-05-20 /pmc/articles/PMC8136714/ /pubmed/34015049 http://dx.doi.org/10.1371/journal.ppat.1009571 Text en © 2021 Dellicour et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Dellicour, Simon
Hong, Samuel L.
Vrancken, Bram
Chaillon, Antoine
Gill, Mandev S.
Maurano, Matthew T.
Ramaswami, Sitharam
Zappile, Paul
Marier, Christian
Harkins, Gordon W.
Baele, Guy
Duerr, Ralf
Heguy, Adriana
Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
title Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
title_full Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
title_fullStr Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
title_full_unstemmed Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
title_short Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
title_sort dispersal dynamics of sars-cov-2 lineages during the first epidemic wave in new york city
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136714/
https://www.ncbi.nlm.nih.gov/pubmed/34015049
http://dx.doi.org/10.1371/journal.ppat.1009571
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