The combination of the NS5A and cyclophilin inhibitors results in an additive anti-HCV inhibition in humanized mice without development of resistance

We and others previously reported that the direct-acting agents (DAA) NS5A inhibitors (NS5Ai) and the host-targeting agents cyclophilin inhibitors (CypIs) inhibit HCV replication in vitro. In this study, we investigated whether the combination of NS5Ai and CypI offers a potent anti-HCV effect in viv...

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Detalles Bibliográficos
Autores principales: Bobardt, Michael, Ramirez, Christina M., Baum, Marc M., Ure, Daren, Foster, Robert, Gallay, Philippe A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136729/
https://www.ncbi.nlm.nih.gov/pubmed/34014993
http://dx.doi.org/10.1371/journal.pone.0251934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136729/
https://www.ncbi.nlm.nih.gov/pubmed/34014993
http://dx.doi.org/10.1371/journal.pone.0251934

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