ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion

ERG family proteins (ERG, FLI1 and FEV) are a subfamily of ETS transcription factors with key roles in physiology and development. In Ewing sarcoma, the oncogenic fusion protein EWS-FLI1 regulates both transcription and alternative splicing of pre-messenger RNAs. However, whether wild-type ERG famil...

Descripción completa

Detalles Bibliográficos
Autores principales: Saulnier, Olivier, Guedri-Idjouadiene, Katia, Aynaud, Marie-Ming, Chakraborty, Alina, Bruyr, Jonathan, Pineau, Joséphine, O’Grady, Tina, Mirabeau, Olivier, Grossetête, Sandrine, Galvan, Bartimée, Claes, Margaux, Al Oula Hassoun, Zahra, Sadacca, Benjamin, Laud, Karine, Zaïdi, Sakina, Surdez, Didier, Baulande, Sylvain, Rambout, Xavier, Tirode, Franck, Dutertre, Martin, Delattre, Olivier, Dequiedt, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136815/
https://www.ncbi.nlm.nih.gov/pubmed/34009296
http://dx.doi.org/10.1093/nar/gkab305

Ejemplares similares

Ejemplares similares