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Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children: A protocol for systematic review and meta-analysis

BACKGROUND: : The gene mutation of coding sodium channel is one of the most important mechanisms in the pathogenesis of epilepsy. There exists a large inter-individual variation in the efficacy of valproic acid (VPA) against epilepsy. What are the genetic polymorphism influences of sodium channels o...

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Autores principales: Wen, Zhuangfei, Chen, Jiang, Zhu, Bin, Lu, Yan, Chen, Lijiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136989/
https://www.ncbi.nlm.nih.gov/pubmed/34011048
http://dx.doi.org/10.1097/MD.0000000000025831
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author Wen, Zhuangfei
Chen, Jiang
Zhu, Bin
Lu, Yan
Chen, Lijiao
author_facet Wen, Zhuangfei
Chen, Jiang
Zhu, Bin
Lu, Yan
Chen, Lijiao
author_sort Wen, Zhuangfei
collection PubMed
description BACKGROUND: : The gene mutation of coding sodium channel is one of the most important mechanisms in the pathogenesis of epilepsy. There exists a large inter-individual variation in the efficacy of valproic acid (VPA) against epilepsy. What are the genetic polymorphism influences of sodium channels on VPA response is still under discussion. In this study, a meta-analysis was used to further explore the effects of SCN1A and SCN2A gene polymorphism on VPA response in children with epilepsy. METHODS: : The PubMed, EMBASE, Web of Science, Chinese National Knowledge Infrastructure, Chinese Science and Technique Journals Database, China Biology Medicine disc, and Wan Fang Database were searched up to April 2021 for appropriate studies regarding the association between SCN1A and SCN2A gene polymorphism on VPA response in children suffering from epilepsy. The meta-analysis was conducted by Review Manager 5.3 software. RESULTS: : The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. CONCLUSION: : This meta-analysis will summarize the effects of SCN1A and SCN2A gene polymorphisms on VPA response in children with epilepsy. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/N2786.
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spelling pubmed-81369892021-05-25 Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children: A protocol for systematic review and meta-analysis Wen, Zhuangfei Chen, Jiang Zhu, Bin Lu, Yan Chen, Lijiao Medicine (Baltimore) 4300 BACKGROUND: : The gene mutation of coding sodium channel is one of the most important mechanisms in the pathogenesis of epilepsy. There exists a large inter-individual variation in the efficacy of valproic acid (VPA) against epilepsy. What are the genetic polymorphism influences of sodium channels on VPA response is still under discussion. In this study, a meta-analysis was used to further explore the effects of SCN1A and SCN2A gene polymorphism on VPA response in children with epilepsy. METHODS: : The PubMed, EMBASE, Web of Science, Chinese National Knowledge Infrastructure, Chinese Science and Technique Journals Database, China Biology Medicine disc, and Wan Fang Database were searched up to April 2021 for appropriate studies regarding the association between SCN1A and SCN2A gene polymorphism on VPA response in children suffering from epilepsy. The meta-analysis was conducted by Review Manager 5.3 software. RESULTS: : The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. CONCLUSION: : This meta-analysis will summarize the effects of SCN1A and SCN2A gene polymorphisms on VPA response in children with epilepsy. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/N2786. Lippincott Williams & Wilkins 2021-05-21 /pmc/articles/PMC8136989/ /pubmed/34011048 http://dx.doi.org/10.1097/MD.0000000000025831 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 4300
Wen, Zhuangfei
Chen, Jiang
Zhu, Bin
Lu, Yan
Chen, Lijiao
Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children: A protocol for systematic review and meta-analysis
title Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children: A protocol for systematic review and meta-analysis
title_full Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children: A protocol for systematic review and meta-analysis
title_fullStr Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children: A protocol for systematic review and meta-analysis
title_full_unstemmed Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children: A protocol for systematic review and meta-analysis
title_short Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children: A protocol for systematic review and meta-analysis
title_sort effects of scn1a and scn2a polymorphisms on responsiveness to valproic acid monotherapy in epileptic children: a protocol for systematic review and meta-analysis
topic 4300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8136989/
https://www.ncbi.nlm.nih.gov/pubmed/34011048
http://dx.doi.org/10.1097/MD.0000000000025831
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