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Epidemiological characteristics of hand, foot, and mouth disease in China: A meta-analysis

BACKGROUND: To study the epidemic features of hand-foot-mouth disease (HFMD) in mainland China through systematic review and meta-analysis so as to provide evidence for the future prevention and control of HFMD. METHODS: Articles on the epidemic features of HFMD in mainland China, written in English...

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Autores principales: Chen, Bo, Yang, Ying, Xu, Xufeng, Zhao, Haixia, Li, Yi, Yin, Shi, Chen, Yong-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137076/
https://www.ncbi.nlm.nih.gov/pubmed/34011066
http://dx.doi.org/10.1097/MD.0000000000025930
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author Chen, Bo
Yang, Ying
Xu, Xufeng
Zhao, Haixia
Li, Yi
Yin, Shi
Chen, Yong-Quan
author_facet Chen, Bo
Yang, Ying
Xu, Xufeng
Zhao, Haixia
Li, Yi
Yin, Shi
Chen, Yong-Quan
author_sort Chen, Bo
collection PubMed
description BACKGROUND: To study the epidemic features of hand-foot-mouth disease (HFMD) in mainland China through systematic review and meta-analysis so as to provide evidence for the future prevention and control of HFMD. METHODS: Articles on the epidemic features of HFMD in mainland China, written in English or Chinese and released between January 1, 2015 and January 1, 2020, were searched from English literature databases including Embase, Web of Science, PubMed, Cochrane library, Google academic, and Chinese literature databases including China national knowledge infrastructure (CNKI), Wanfang, and China Biology Medicine (CBM). Papers were selected according to the inclusion and exclusion criteria, and quality scoring was performed. Meta-analysis, sensitivity analysis, and identification of publication bias were finished through STATA version 12.0 software. RESULTS: A total of 23 articles were included in this study, the total number of cases was 377,083, of which the total number of male cases was 231,798 and the total number of female cases was 145,285, the sex ratio was about 1.6:1, and the incidence of HFMD in China was 1.61‰ (95% confidence interval [CI]: 1.21‰–1.94‰). The results of the subgroup analysis showed that the incidence of HFMD in mainland China was the highest in South China, in 2014, in 1-year-old group and in other types of enteroviruses, respectively, with the rate of 3.48‰ (95% CI: 1.22‰–5.73‰), 1.81‰ (95% CI: 1.06‰–2.57‰), 15.20‰ (95% CI: 5.00‰–25.30‰), and 1.83‰ (95% CI: 1.32‰–2.33‰), respectively. The differences among the above 4 subgroups were statistically significant (P < .05). There were no publication bias in this study, and the sensitivity analysis results suggested that the meta-analysis results were robust. CONCLUSION: There were differences in the distribution of region, time, population, and etiology of HFMD in mainland China. Health departments should adopt key strategies and measures for key populations in key areas to prevent and control the development of HFMD, and improve the ability of pathogen detection and typing in laboratories.
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spelling pubmed-81370762021-05-25 Epidemiological characteristics of hand, foot, and mouth disease in China: A meta-analysis Chen, Bo Yang, Ying Xu, Xufeng Zhao, Haixia Li, Yi Yin, Shi Chen, Yong-Quan Medicine (Baltimore) 4400 BACKGROUND: To study the epidemic features of hand-foot-mouth disease (HFMD) in mainland China through systematic review and meta-analysis so as to provide evidence for the future prevention and control of HFMD. METHODS: Articles on the epidemic features of HFMD in mainland China, written in English or Chinese and released between January 1, 2015 and January 1, 2020, were searched from English literature databases including Embase, Web of Science, PubMed, Cochrane library, Google academic, and Chinese literature databases including China national knowledge infrastructure (CNKI), Wanfang, and China Biology Medicine (CBM). Papers were selected according to the inclusion and exclusion criteria, and quality scoring was performed. Meta-analysis, sensitivity analysis, and identification of publication bias were finished through STATA version 12.0 software. RESULTS: A total of 23 articles were included in this study, the total number of cases was 377,083, of which the total number of male cases was 231,798 and the total number of female cases was 145,285, the sex ratio was about 1.6:1, and the incidence of HFMD in China was 1.61‰ (95% confidence interval [CI]: 1.21‰–1.94‰). The results of the subgroup analysis showed that the incidence of HFMD in mainland China was the highest in South China, in 2014, in 1-year-old group and in other types of enteroviruses, respectively, with the rate of 3.48‰ (95% CI: 1.22‰–5.73‰), 1.81‰ (95% CI: 1.06‰–2.57‰), 15.20‰ (95% CI: 5.00‰–25.30‰), and 1.83‰ (95% CI: 1.32‰–2.33‰), respectively. The differences among the above 4 subgroups were statistically significant (P < .05). There were no publication bias in this study, and the sensitivity analysis results suggested that the meta-analysis results were robust. CONCLUSION: There were differences in the distribution of region, time, population, and etiology of HFMD in mainland China. Health departments should adopt key strategies and measures for key populations in key areas to prevent and control the development of HFMD, and improve the ability of pathogen detection and typing in laboratories. Lippincott Williams & Wilkins 2021-05-21 /pmc/articles/PMC8137076/ /pubmed/34011066 http://dx.doi.org/10.1097/MD.0000000000025930 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 4400
Chen, Bo
Yang, Ying
Xu, Xufeng
Zhao, Haixia
Li, Yi
Yin, Shi
Chen, Yong-Quan
Epidemiological characteristics of hand, foot, and mouth disease in China: A meta-analysis
title Epidemiological characteristics of hand, foot, and mouth disease in China: A meta-analysis
title_full Epidemiological characteristics of hand, foot, and mouth disease in China: A meta-analysis
title_fullStr Epidemiological characteristics of hand, foot, and mouth disease in China: A meta-analysis
title_full_unstemmed Epidemiological characteristics of hand, foot, and mouth disease in China: A meta-analysis
title_short Epidemiological characteristics of hand, foot, and mouth disease in China: A meta-analysis
title_sort epidemiological characteristics of hand, foot, and mouth disease in china: a meta-analysis
topic 4400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137076/
https://www.ncbi.nlm.nih.gov/pubmed/34011066
http://dx.doi.org/10.1097/MD.0000000000025930
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