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Prevalence of peripheral neuropathy in pre-diabetes: a systematic review

There is growing evidence of excess peripheral neuropathy in pre-diabetes. We aimed to determine its prevalence, including the impact of diagnostic methodology on prevalence rates, through a systematic review conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses g...

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Autores principales: Kirthi, Varo, Perumbalath, Anugraha, Brown, Emily, Nevitt, Sarah, Petropoulos, Ioannis N, Burgess, Jamie, Roylance, Rebecca, Cuthbertson, Daniel J, Jackson, Timothy L, Malik, Rayaz A, Alam, Uazman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137250/
https://www.ncbi.nlm.nih.gov/pubmed/34006607
http://dx.doi.org/10.1136/bmjdrc-2020-002040
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author Kirthi, Varo
Perumbalath, Anugraha
Brown, Emily
Nevitt, Sarah
Petropoulos, Ioannis N
Burgess, Jamie
Roylance, Rebecca
Cuthbertson, Daniel J
Jackson, Timothy L
Malik, Rayaz A
Alam, Uazman
author_facet Kirthi, Varo
Perumbalath, Anugraha
Brown, Emily
Nevitt, Sarah
Petropoulos, Ioannis N
Burgess, Jamie
Roylance, Rebecca
Cuthbertson, Daniel J
Jackson, Timothy L
Malik, Rayaz A
Alam, Uazman
author_sort Kirthi, Varo
collection PubMed
description There is growing evidence of excess peripheral neuropathy in pre-diabetes. We aimed to determine its prevalence, including the impact of diagnostic methodology on prevalence rates, through a systematic review conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive electronic bibliographic search was performed in MEDLINE, EMBASE, PubMed, Web of Science and the Cochrane Central Register of Controlled Trials from inception to June 1, 2020. Two reviewers independently selected studies, extracted data and assessed risk of bias. An evaluation was undertaken by method of neuropathy assessment. After screening 1784 abstracts and reviewing 84 full-text records, 29 studies (9351 participants) were included. There was a wide range of prevalence estimates (2%–77%, IQR: 6%–34%), but the majority of studies (n=21, 72%) reported a prevalence ≥10%. The three highest prevalence estimates of 77% (95% CI: 54% to 100%), 71% (95% CI: 55% to 88%) and 66% (95% CI: 53% to 78%) were reported using plantar thermography, multimodal quantitative sensory testing and nerve conduction tests, respectively. In general, studies evaluating small nerve fiber parameters yielded a higher prevalence of peripheral neuropathy. Due to a variety of study populations and methods of assessing neuropathy, there was marked heterogeneity in the prevalence estimates. Most studies reported a higher prevalence of peripheral neuropathy in pre-diabetes, primarily of a small nerve fiber origin, than would be expected in the background population. Given the marked rise in pre-diabetes, further consideration of targeting screening in this population is required. Development of risk-stratification tools may facilitate earlier interventions.
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spelling pubmed-81372502021-06-01 Prevalence of peripheral neuropathy in pre-diabetes: a systematic review Kirthi, Varo Perumbalath, Anugraha Brown, Emily Nevitt, Sarah Petropoulos, Ioannis N Burgess, Jamie Roylance, Rebecca Cuthbertson, Daniel J Jackson, Timothy L Malik, Rayaz A Alam, Uazman BMJ Open Diabetes Res Care Pathophysiology/Complications There is growing evidence of excess peripheral neuropathy in pre-diabetes. We aimed to determine its prevalence, including the impact of diagnostic methodology on prevalence rates, through a systematic review conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive electronic bibliographic search was performed in MEDLINE, EMBASE, PubMed, Web of Science and the Cochrane Central Register of Controlled Trials from inception to June 1, 2020. Two reviewers independently selected studies, extracted data and assessed risk of bias. An evaluation was undertaken by method of neuropathy assessment. After screening 1784 abstracts and reviewing 84 full-text records, 29 studies (9351 participants) were included. There was a wide range of prevalence estimates (2%–77%, IQR: 6%–34%), but the majority of studies (n=21, 72%) reported a prevalence ≥10%. The three highest prevalence estimates of 77% (95% CI: 54% to 100%), 71% (95% CI: 55% to 88%) and 66% (95% CI: 53% to 78%) were reported using plantar thermography, multimodal quantitative sensory testing and nerve conduction tests, respectively. In general, studies evaluating small nerve fiber parameters yielded a higher prevalence of peripheral neuropathy. Due to a variety of study populations and methods of assessing neuropathy, there was marked heterogeneity in the prevalence estimates. Most studies reported a higher prevalence of peripheral neuropathy in pre-diabetes, primarily of a small nerve fiber origin, than would be expected in the background population. Given the marked rise in pre-diabetes, further consideration of targeting screening in this population is required. Development of risk-stratification tools may facilitate earlier interventions. BMJ Publishing Group 2021-05-18 /pmc/articles/PMC8137250/ /pubmed/34006607 http://dx.doi.org/10.1136/bmjdrc-2020-002040 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Pathophysiology/Complications
Kirthi, Varo
Perumbalath, Anugraha
Brown, Emily
Nevitt, Sarah
Petropoulos, Ioannis N
Burgess, Jamie
Roylance, Rebecca
Cuthbertson, Daniel J
Jackson, Timothy L
Malik, Rayaz A
Alam, Uazman
Prevalence of peripheral neuropathy in pre-diabetes: a systematic review
title Prevalence of peripheral neuropathy in pre-diabetes: a systematic review
title_full Prevalence of peripheral neuropathy in pre-diabetes: a systematic review
title_fullStr Prevalence of peripheral neuropathy in pre-diabetes: a systematic review
title_full_unstemmed Prevalence of peripheral neuropathy in pre-diabetes: a systematic review
title_short Prevalence of peripheral neuropathy in pre-diabetes: a systematic review
title_sort prevalence of peripheral neuropathy in pre-diabetes: a systematic review
topic Pathophysiology/Complications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137250/
https://www.ncbi.nlm.nih.gov/pubmed/34006607
http://dx.doi.org/10.1136/bmjdrc-2020-002040
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