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Status of Sentinel Lymph Node Biopsy in Endometrial Cancer

The role of lymphadenectomy in surgical staging remains one of the biggest controversies in the management of endometrial cancer. The concept of sentinel lymph node biopsy in endometrial cancer has been evaluated for a number of years, with promising sensitivity rates and negative predictive values....

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Autores principales: Taran, Florin Andrei, Jung, Lisa, Waldschmidt, Julia, Huwer, Sarah Isabelle, Juhasz-Böss, Ingolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137276/
https://www.ncbi.nlm.nih.gov/pubmed/34035551
http://dx.doi.org/10.1055/a-1228-6189
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author Taran, Florin Andrei
Jung, Lisa
Waldschmidt, Julia
Huwer, Sarah Isabelle
Juhasz-Böss, Ingolf
author_facet Taran, Florin Andrei
Jung, Lisa
Waldschmidt, Julia
Huwer, Sarah Isabelle
Juhasz-Böss, Ingolf
author_sort Taran, Florin Andrei
collection PubMed
description The role of lymphadenectomy in surgical staging remains one of the biggest controversies in the management of endometrial cancer. The concept of sentinel lymph node biopsy in endometrial cancer has been evaluated for a number of years, with promising sensitivity rates and negative predictive values. The possibility of adequate staging while avoiding systematic lymphadenectomy leads to a significant reduction in the rate of peri- and postoperative morbidity. Nevertheless, the status of sentinel lymph node biopsy in endometrial cancer has not yet been fully elucidated and is variously assessed internationally. According to current European guidelines and recommendations, sentinel lymph node biopsy in endometrial cancer should be performed only in the context of clinical studies. In this review article, the developments of the past decade are explored concisely. In addition, current data regarding the technical aspects, accuracy and prognostic relevance of sentinel lymph node biopsy are explained and evaluated critically.
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spelling pubmed-81372762021-05-24 Status of Sentinel Lymph Node Biopsy in Endometrial Cancer Taran, Florin Andrei Jung, Lisa Waldschmidt, Julia Huwer, Sarah Isabelle Juhasz-Böss, Ingolf Geburtshilfe Frauenheilkd The role of lymphadenectomy in surgical staging remains one of the biggest controversies in the management of endometrial cancer. The concept of sentinel lymph node biopsy in endometrial cancer has been evaluated for a number of years, with promising sensitivity rates and negative predictive values. The possibility of adequate staging while avoiding systematic lymphadenectomy leads to a significant reduction in the rate of peri- and postoperative morbidity. Nevertheless, the status of sentinel lymph node biopsy in endometrial cancer has not yet been fully elucidated and is variously assessed internationally. According to current European guidelines and recommendations, sentinel lymph node biopsy in endometrial cancer should be performed only in the context of clinical studies. In this review article, the developments of the past decade are explored concisely. In addition, current data regarding the technical aspects, accuracy and prognostic relevance of sentinel lymph node biopsy are explained and evaluated critically. Georg Thieme Verlag KG 2021-05 2021-05-20 /pmc/articles/PMC8137276/ /pubmed/34035551 http://dx.doi.org/10.1055/a-1228-6189 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Taran, Florin Andrei
Jung, Lisa
Waldschmidt, Julia
Huwer, Sarah Isabelle
Juhasz-Böss, Ingolf
Status of Sentinel Lymph Node Biopsy in Endometrial Cancer
title Status of Sentinel Lymph Node Biopsy in Endometrial Cancer
title_full Status of Sentinel Lymph Node Biopsy in Endometrial Cancer
title_fullStr Status of Sentinel Lymph Node Biopsy in Endometrial Cancer
title_full_unstemmed Status of Sentinel Lymph Node Biopsy in Endometrial Cancer
title_short Status of Sentinel Lymph Node Biopsy in Endometrial Cancer
title_sort status of sentinel lymph node biopsy in endometrial cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137276/
https://www.ncbi.nlm.nih.gov/pubmed/34035551
http://dx.doi.org/10.1055/a-1228-6189
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