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Recurrent Bilateral Strokes in a Patient Treated With Sipuleucel-T for Prostate Cancer
Sipuleucel-T is approved by the US Food and Drug Administration (FDA) for the treatment of castration-resistant prostate cancer (CRPC). Herein, we present a patient with recurrent bilateral embolic stroke who was on sipuleucel-T therapy for CRPC. Laboratory and imaging data didn’t reveal any source...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137308/ https://www.ncbi.nlm.nih.gov/pubmed/34036014 http://dx.doi.org/10.7759/cureus.14596 |
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author | Gill, Jashan Jeelani, Hafiz Muhammad Prasad, Sonika Tahir, Nayha |
author_facet | Gill, Jashan Jeelani, Hafiz Muhammad Prasad, Sonika Tahir, Nayha |
author_sort | Gill, Jashan |
collection | PubMed |
description | Sipuleucel-T is approved by the US Food and Drug Administration (FDA) for the treatment of castration-resistant prostate cancer (CRPC). Herein, we present a patient with recurrent bilateral embolic stroke who was on sipuleucel-T therapy for CRPC. Laboratory and imaging data didn’t reveal any source of embolic stroke. A focused history disclosed that the patient received two doses of sipuleucel-T before the first stroke and was advised not to receive his third dose. He reported no other episode of stroke at the six-month follow-up. This case highlights the importance of identifying sipuleucel-T as a potential cause of embolic stroke if the source is not detectable, as discontinuing the therapy can be beneficial. Physicians should evaluate patients for risk of stroke before starting the therapy to prevent future strokes. |
format | Online Article Text |
id | pubmed-8137308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-81373082021-05-24 Recurrent Bilateral Strokes in a Patient Treated With Sipuleucel-T for Prostate Cancer Gill, Jashan Jeelani, Hafiz Muhammad Prasad, Sonika Tahir, Nayha Cureus Neurology Sipuleucel-T is approved by the US Food and Drug Administration (FDA) for the treatment of castration-resistant prostate cancer (CRPC). Herein, we present a patient with recurrent bilateral embolic stroke who was on sipuleucel-T therapy for CRPC. Laboratory and imaging data didn’t reveal any source of embolic stroke. A focused history disclosed that the patient received two doses of sipuleucel-T before the first stroke and was advised not to receive his third dose. He reported no other episode of stroke at the six-month follow-up. This case highlights the importance of identifying sipuleucel-T as a potential cause of embolic stroke if the source is not detectable, as discontinuing the therapy can be beneficial. Physicians should evaluate patients for risk of stroke before starting the therapy to prevent future strokes. Cureus 2021-04-20 /pmc/articles/PMC8137308/ /pubmed/34036014 http://dx.doi.org/10.7759/cureus.14596 Text en Copyright © 2021, Gill et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Neurology Gill, Jashan Jeelani, Hafiz Muhammad Prasad, Sonika Tahir, Nayha Recurrent Bilateral Strokes in a Patient Treated With Sipuleucel-T for Prostate Cancer |
title | Recurrent Bilateral Strokes in a Patient Treated With Sipuleucel-T for Prostate Cancer |
title_full | Recurrent Bilateral Strokes in a Patient Treated With Sipuleucel-T for Prostate Cancer |
title_fullStr | Recurrent Bilateral Strokes in a Patient Treated With Sipuleucel-T for Prostate Cancer |
title_full_unstemmed | Recurrent Bilateral Strokes in a Patient Treated With Sipuleucel-T for Prostate Cancer |
title_short | Recurrent Bilateral Strokes in a Patient Treated With Sipuleucel-T for Prostate Cancer |
title_sort | recurrent bilateral strokes in a patient treated with sipuleucel-t for prostate cancer |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137308/ https://www.ncbi.nlm.nih.gov/pubmed/34036014 http://dx.doi.org/10.7759/cureus.14596 |
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