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The change in high-sensitivity troponin-T as a risk factor for significant coronary stenosis in patients with acute coronary syndrome
BACKGROUND/AIMS: High-sensitivity cardiac troponin (hs-TnT) assays detect very low levels of cardiac troponin. This study examined the interval change between initial and subsequent hs-TnT levels and evaluated its ability to predict significant coronary stenosis. METHODS: The study analyzed 163 pati...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Internal Medicine
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137410/ https://www.ncbi.nlm.nih.gov/pubmed/33395738 http://dx.doi.org/10.3904/kjim.2020.090 |
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author | Kim, Min Chul Oh, Seok Ahn, Youngkeun Moon, Keumyi Ahn, Joon Ho Hyun, Dae Young Cho, Kyung Hoon Sim, Doo Sun Hong, Young Joon Kim, Ju Han Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun |
author_facet | Kim, Min Chul Oh, Seok Ahn, Youngkeun Moon, Keumyi Ahn, Joon Ho Hyun, Dae Young Cho, Kyung Hoon Sim, Doo Sun Hong, Young Joon Kim, Ju Han Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun |
author_sort | Kim, Min Chul |
collection | PubMed |
description | BACKGROUND/AIMS: High-sensitivity cardiac troponin (hs-TnT) assays detect very low levels of cardiac troponin. This study examined the interval change between initial and subsequent hs-TnT levels and evaluated its ability to predict significant coronary stenosis. METHODS: The study analyzed 163 patients who presented with acute coronary syndrome (ACS) and underwent coronary angiography (CAG) between April 2014 and May 2018. The 0 and 3-hour hs-TnT were checked. The patients were subdivided into positive (n = 32) and negative (n = 131) interval change groups. The presence of significant coronary artery stenosis on CAG in the two groups was compared. RESULTS: The positive interval change group was older and had higher 0 and 3-hour hs-TnT and blood glucose levels than the negative interval change group. Significant coronary stenosis was more common in the positive interval change group than in the negative interval change group (68.8% vs. 23.7%, p = 0.001). However, vasospasm was more common in the negative interval change group (6.3% vs. 31.3%, p = 0.003). The positive interval change group had higher rates of bifurcation lesions and received more percutaneous coronary intervention. In multivariate analysis, age, interval change of serial hs-TnT and diabetes mellitus were independent predictors of significant coronary artery stenosis. CONCLUSIONS: This study identified a relationship between the serial change in cardiac biomarkers and the presence of significant coronary stenosis in patients with ACS. Serial hs-TnT change was associated with real angiographic stenosis in patients with ACS. |
format | Online Article Text |
id | pubmed-8137410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-81374102021-05-28 The change in high-sensitivity troponin-T as a risk factor for significant coronary stenosis in patients with acute coronary syndrome Kim, Min Chul Oh, Seok Ahn, Youngkeun Moon, Keumyi Ahn, Joon Ho Hyun, Dae Young Cho, Kyung Hoon Sim, Doo Sun Hong, Young Joon Kim, Ju Han Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun Korean J Intern Med Original Article BACKGROUND/AIMS: High-sensitivity cardiac troponin (hs-TnT) assays detect very low levels of cardiac troponin. This study examined the interval change between initial and subsequent hs-TnT levels and evaluated its ability to predict significant coronary stenosis. METHODS: The study analyzed 163 patients who presented with acute coronary syndrome (ACS) and underwent coronary angiography (CAG) between April 2014 and May 2018. The 0 and 3-hour hs-TnT were checked. The patients were subdivided into positive (n = 32) and negative (n = 131) interval change groups. The presence of significant coronary artery stenosis on CAG in the two groups was compared. RESULTS: The positive interval change group was older and had higher 0 and 3-hour hs-TnT and blood glucose levels than the negative interval change group. Significant coronary stenosis was more common in the positive interval change group than in the negative interval change group (68.8% vs. 23.7%, p = 0.001). However, vasospasm was more common in the negative interval change group (6.3% vs. 31.3%, p = 0.003). The positive interval change group had higher rates of bifurcation lesions and received more percutaneous coronary intervention. In multivariate analysis, age, interval change of serial hs-TnT and diabetes mellitus were independent predictors of significant coronary artery stenosis. CONCLUSIONS: This study identified a relationship between the serial change in cardiac biomarkers and the presence of significant coronary stenosis in patients with ACS. Serial hs-TnT change was associated with real angiographic stenosis in patients with ACS. The Korean Association of Internal Medicine 2021-05 2021-01-04 /pmc/articles/PMC8137410/ /pubmed/33395738 http://dx.doi.org/10.3904/kjim.2020.090 Text en Copyright © 2021 The Korean Association of Internal Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Min Chul Oh, Seok Ahn, Youngkeun Moon, Keumyi Ahn, Joon Ho Hyun, Dae Young Cho, Kyung Hoon Sim, Doo Sun Hong, Young Joon Kim, Ju Han Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun The change in high-sensitivity troponin-T as a risk factor for significant coronary stenosis in patients with acute coronary syndrome |
title | The change in high-sensitivity troponin-T as a risk factor for significant coronary stenosis in patients with acute coronary syndrome |
title_full | The change in high-sensitivity troponin-T as a risk factor for significant coronary stenosis in patients with acute coronary syndrome |
title_fullStr | The change in high-sensitivity troponin-T as a risk factor for significant coronary stenosis in patients with acute coronary syndrome |
title_full_unstemmed | The change in high-sensitivity troponin-T as a risk factor for significant coronary stenosis in patients with acute coronary syndrome |
title_short | The change in high-sensitivity troponin-T as a risk factor for significant coronary stenosis in patients with acute coronary syndrome |
title_sort | change in high-sensitivity troponin-t as a risk factor for significant coronary stenosis in patients with acute coronary syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137410/ https://www.ncbi.nlm.nih.gov/pubmed/33395738 http://dx.doi.org/10.3904/kjim.2020.090 |
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