Systems Modeling to Quantify Safety Risks in Early Drug Development: Using Bifurcation Analysis and Agent-Based Modeling as Examples

Quantitative Systems Toxicology (QST) models, recapitulating pharmacokinetics and mechanism of action together with the organic response at multiple levels of biological organization, can provide predictions on the magnitude of injury and recovery dynamics to support study design and decision-making...

Descripción completa

Detalles Bibliográficos
Autores principales: Pin, Carmen, Collins, Teresa, Gibbs, Megan, Kimko, Holly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137611/
https://www.ncbi.nlm.nih.gov/pubmed/34018069
http://dx.doi.org/10.1208/s12248-021-00580-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137611/
https://www.ncbi.nlm.nih.gov/pubmed/34018069
http://dx.doi.org/10.1208/s12248-021-00580-2

Ejemplares similares