Inhibitory synaptic transmission is impaired at higher extracellular Ca(2+) concentrations in Scn1a(+/−) mouse model of Dravet syndrome

Dravet syndrome (DS) is an intractable form of childhood epilepsy that occurs in infancy. More than 80% of all patients have a heterozygous abnormality in the SCN1A gene, which encodes a subunit of Na(+) channels in the brain. However, the detailed pathogenesis of DS remains unclear. This study inve...

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Detalles Bibliográficos
Autores principales: Uchino, Kouya, Kawano, Hiroyuki, Tanaka, Yasuyoshi, Adaniya, Yuna, Asahara, Ai, Deshimaru, Masanobu, Kubota, Kaori, Watanabe, Takuya, Katsurabayashi, Shutaro, Iwasaki, Katsunori, Hirose, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137694/
https://www.ncbi.nlm.nih.gov/pubmed/34017040
http://dx.doi.org/10.1038/s41598-021-90224-4

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