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USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS

Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS activation are not completely understood. Ubiquitination has a central function in regulating the activity of MAVS. Here, we demonstra...

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Detalles Bibliográficos
Autores principales:	Hou, Jinxiu, Han, Lulu, Zhao, Ze, Liu, Huiqing, Zhang, Lei, Ma, Chunhong, Yi, Fan, Liu, Bingyu, Zheng, Yi, Gao, Chengjiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137702/ https://www.ncbi.nlm.nih.gov/pubmed/34016972 http://dx.doi.org/10.1038/s41467-021-23219-4

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