TIGIT and PD-1 Immune Checkpoint Pathways Are Associated With Patient Outcome and Anti-Tumor Immunity in Glioblastoma

Glioblastoma (GBM) remains an aggressive brain tumor with a high rate of mortality. Immune checkpoint (IC) molecules are expressed on tumor infiltrating lymphocytes (TILs) and promote T cell exhaustion upon binding to IC ligands expressed by the tumor cells. Interfering with IC pathways with immunot...

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Detalles Bibliográficos
Autores principales: Raphael, Itay, Kumar, Rajeev, McCarl, Lauren H., Shoger, Karsen, Wang, Lin, Sandlesh, Poorva, Sneiderman, Chaim T., Allen, Jordan, Zhai, Shuyan, Campagna, Marissa Lynn, Foster, Alexandra, Bruno, Tullia C., Agnihotri, Sameer, Hu, Baoli, Castro, Brandyn A., Lieberman, Frank S., Broniscer, Alberto, Diaz, Aaron A., Amankulor, Nduka M., Rajasundaram, Dhivyaa, Pollack, Ian F., Kohanbash, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137816/
https://www.ncbi.nlm.nih.gov/pubmed/34025646
http://dx.doi.org/10.3389/fimmu.2021.637146

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