MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway

The regulation of microRNA (miRNA) is closely related to methamphetamine (METH) addiction. Past studies have reported that miR-181a is associated with METH addiction, but the mechanism pathways remain elusive. On the basis of our past studies, which reported the endoplasmic reticulum-associated prot...

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Detalles Bibliográficos
Autores principales: Wang, Yujing, Wei, Tao, Zhao, Wei, Ren, Zixuan, Wang, Yan, Zhou, Yiding, Song, Xun, Zhou, Ruidong, Zhang, Xiaochu, Jiao, Dongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137846/
https://www.ncbi.nlm.nih.gov/pubmed/34025353
http://dx.doi.org/10.3389/fnmol.2021.667725
Descripción
Sumario:The regulation of microRNA (miRNA) is closely related to methamphetamine (METH) addiction. Past studies have reported that miR-181a is associated with METH addiction, but the mechanism pathways remain elusive. On the basis of our past studies, which reported the endoplasmic reticulum-associated protein degradation (ERAD) mediated ubiquitin protein degradation of GABAAα1, which was involved in METH addiction. The present study, using qRT-PCR and bioinformatics analysis, further revealed that miR-181a may be indirectly responsible for the METH addiction and downregulation of GABAAα1 through the regulation of ERAD.

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