MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway

The regulation of microRNA (miRNA) is closely related to methamphetamine (METH) addiction. Past studies have reported that miR-181a is associated with METH addiction, but the mechanism pathways remain elusive. On the basis of our past studies, which reported the endoplasmic reticulum-associated prot...

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Autores principales: Wang, Yujing, Wei, Tao, Zhao, Wei, Ren, Zixuan, Wang, Yan, Zhou, Yiding, Song, Xun, Zhou, Ruidong, Zhang, Xiaochu, Jiao, Dongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137846/
https://www.ncbi.nlm.nih.gov/pubmed/34025353
http://dx.doi.org/10.3389/fnmol.2021.667725
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author Wang, Yujing
Wei, Tao
Zhao, Wei
Ren, Zixuan
Wang, Yan
Zhou, Yiding
Song, Xun
Zhou, Ruidong
Zhang, Xiaochu
Jiao, Dongliang
author_facet Wang, Yujing
Wei, Tao
Zhao, Wei
Ren, Zixuan
Wang, Yan
Zhou, Yiding
Song, Xun
Zhou, Ruidong
Zhang, Xiaochu
Jiao, Dongliang
author_sort Wang, Yujing
collection PubMed
description The regulation of microRNA (miRNA) is closely related to methamphetamine (METH) addiction. Past studies have reported that miR-181a is associated with METH addiction, but the mechanism pathways remain elusive. On the basis of our past studies, which reported the endoplasmic reticulum-associated protein degradation (ERAD) mediated ubiquitin protein degradation of GABAAα1, which was involved in METH addiction. The present study, using qRT-PCR and bioinformatics analysis, further revealed that miR-181a may be indirectly responsible for the METH addiction and downregulation of GABAAα1 through the regulation of ERAD.
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spelling pubmed-81378462021-05-22 MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway Wang, Yujing Wei, Tao Zhao, Wei Ren, Zixuan Wang, Yan Zhou, Yiding Song, Xun Zhou, Ruidong Zhang, Xiaochu Jiao, Dongliang Front Mol Neurosci Neuroscience The regulation of microRNA (miRNA) is closely related to methamphetamine (METH) addiction. Past studies have reported that miR-181a is associated with METH addiction, but the mechanism pathways remain elusive. On the basis of our past studies, which reported the endoplasmic reticulum-associated protein degradation (ERAD) mediated ubiquitin protein degradation of GABAAα1, which was involved in METH addiction. The present study, using qRT-PCR and bioinformatics analysis, further revealed that miR-181a may be indirectly responsible for the METH addiction and downregulation of GABAAα1 through the regulation of ERAD. Frontiers Media S.A. 2021-05-07 /pmc/articles/PMC8137846/ /pubmed/34025353 http://dx.doi.org/10.3389/fnmol.2021.667725 Text en Copyright © 2021 Wang, Wei, Zhao, Ren, Wang, Zhou, Song, Zhou, Zhang and Jiao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Yujing
Wei, Tao
Zhao, Wei
Ren, Zixuan
Wang, Yan
Zhou, Yiding
Song, Xun
Zhou, Ruidong
Zhang, Xiaochu
Jiao, Dongliang
MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway
title MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway
title_full MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway
title_fullStr MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway
title_full_unstemmed MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway
title_short MicroRNA-181a Is Involved in Methamphetamine Addiction Through the ERAD Pathway
title_sort microrna-181a is involved in methamphetamine addiction through the erad pathway
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137846/
https://www.ncbi.nlm.nih.gov/pubmed/34025353
http://dx.doi.org/10.3389/fnmol.2021.667725
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