Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer

Oncogenic KRAS mutations combined with the loss of the LKB1 tumor-suppressor gene (KL) are strongly associated with aggressive forms of lung cancer. N6-methyladenosine (m6A) in mRNA is a crucial epigenetic modification that controls cancer self-renewal and progression. However, the regulation and ro...

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Detalles Bibliográficos
Autores principales: Zhang, Donghong, Ning, Jinfeng, Okon, Imoh, Zheng, Xiaoxu, Satyanarayana, Ganesh, Song, Ping, Xu, Shidong, Zou, Ming-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137886/
https://www.ncbi.nlm.nih.gov/pubmed/34016959
http://dx.doi.org/10.1038/s41419-021-03793-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137886/
https://www.ncbi.nlm.nih.gov/pubmed/34016959
http://dx.doi.org/10.1038/s41419-021-03793-7

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