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TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread
Rapid death of infected cells is an important antiviral strategy. However, fast decisions that are based on limited evidence can be erroneous and cause unnecessary cell death and subsequent tissue damage. How cells optimize their death decision making strategy to maximize both speed and accuracy is...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137918/ https://www.ncbi.nlm.nih.gov/pubmed/34016976 http://dx.doi.org/10.1038/s41467-021-23195-9 |
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author | Oyler-Yaniv, Jennifer Oyler-Yaniv, Alon Maltz, Evan Wollman, Roy |
author_facet | Oyler-Yaniv, Jennifer Oyler-Yaniv, Alon Maltz, Evan Wollman, Roy |
author_sort | Oyler-Yaniv, Jennifer |
collection | PubMed |
description | Rapid death of infected cells is an important antiviral strategy. However, fast decisions that are based on limited evidence can be erroneous and cause unnecessary cell death and subsequent tissue damage. How cells optimize their death decision making strategy to maximize both speed and accuracy is unclear. Here, we show that exposure to TNF, which is secreted by macrophages during viral infection, causes cells to change their decision strategy from “slow and accurate” to “fast and error-prone”. Mathematical modeling combined with experiments in cell culture and whole organ culture show that the regulation of the cell death decision strategy is critical to prevent HSV-1 spread. These findings demonstrate that immune regulation of cellular cognitive processes dynamically changes a tissues’ tolerance for self-damage, which is required to protect against viral spread. |
format | Online Article Text |
id | pubmed-8137918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81379182021-06-03 TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread Oyler-Yaniv, Jennifer Oyler-Yaniv, Alon Maltz, Evan Wollman, Roy Nat Commun Article Rapid death of infected cells is an important antiviral strategy. However, fast decisions that are based on limited evidence can be erroneous and cause unnecessary cell death and subsequent tissue damage. How cells optimize their death decision making strategy to maximize both speed and accuracy is unclear. Here, we show that exposure to TNF, which is secreted by macrophages during viral infection, causes cells to change their decision strategy from “slow and accurate” to “fast and error-prone”. Mathematical modeling combined with experiments in cell culture and whole organ culture show that the regulation of the cell death decision strategy is critical to prevent HSV-1 spread. These findings demonstrate that immune regulation of cellular cognitive processes dynamically changes a tissues’ tolerance for self-damage, which is required to protect against viral spread. Nature Publishing Group UK 2021-05-20 /pmc/articles/PMC8137918/ /pubmed/34016976 http://dx.doi.org/10.1038/s41467-021-23195-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Oyler-Yaniv, Jennifer Oyler-Yaniv, Alon Maltz, Evan Wollman, Roy TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread |
title | TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread |
title_full | TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread |
title_fullStr | TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread |
title_full_unstemmed | TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread |
title_short | TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread |
title_sort | tnf controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137918/ https://www.ncbi.nlm.nih.gov/pubmed/34016976 http://dx.doi.org/10.1038/s41467-021-23195-9 |
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