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Structural basis for allosteric regulation of Human Topoisomerase IIα

The human type IIA topoisomerases (Top2) are essential enzymes that regulate DNA topology and chromosome organization. The Topo IIα isoform is a prime target for antineoplastic compounds used in cancer therapy that form ternary cleavage complexes with the DNA. Despite extensive studies, structural i...

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Detalles Bibliográficos
Autores principales:	Vanden Broeck, Arnaud, Lotz, Christophe, Drillien, Robert, Haas, Léa, Bedez, Claire, Lamour, Valérie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137924/ https://www.ncbi.nlm.nih.gov/pubmed/34016969 http://dx.doi.org/10.1038/s41467-021-23136-6

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