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Distinct place cell dynamics in CA1 and CA3 encode experience in new environments

When exploring new environments animals form spatial memories that are updated with experience and retrieved upon re-exposure to the same environment. The hippocampus is thought to support these memory processes, but how this is achieved by different subnetworks such as CA1 and CA3 remains unclear....

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Detalles Bibliográficos
Autores principales: Dong, Can, Madar, Antoine D., Sheffield, Mark E. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137926/
https://www.ncbi.nlm.nih.gov/pubmed/34016996
http://dx.doi.org/10.1038/s41467-021-23260-3
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author Dong, Can
Madar, Antoine D.
Sheffield, Mark E. J.
author_facet Dong, Can
Madar, Antoine D.
Sheffield, Mark E. J.
author_sort Dong, Can
collection PubMed
description When exploring new environments animals form spatial memories that are updated with experience and retrieved upon re-exposure to the same environment. The hippocampus is thought to support these memory processes, but how this is achieved by different subnetworks such as CA1 and CA3 remains unclear. To understand how hippocampal spatial representations emerge and evolve during familiarization, we performed 2-photon calcium imaging in mice running in new virtual environments and compared the trial-to-trial dynamics of place cells in CA1 and CA3 over days. We find that place fields in CA1 emerge rapidly but tend to shift backwards from trial-to-trial and remap upon re-exposure to the environment a day later. In contrast, place fields in CA3 emerge gradually but show more stable trial-to-trial and day-to-day dynamics. These results reflect different roles in CA1 and CA3 in spatial memory processing during familiarization to new environments and constrain the potential mechanisms that support them.
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spelling pubmed-81379262021-06-03 Distinct place cell dynamics in CA1 and CA3 encode experience in new environments Dong, Can Madar, Antoine D. Sheffield, Mark E. J. Nat Commun Article When exploring new environments animals form spatial memories that are updated with experience and retrieved upon re-exposure to the same environment. The hippocampus is thought to support these memory processes, but how this is achieved by different subnetworks such as CA1 and CA3 remains unclear. To understand how hippocampal spatial representations emerge and evolve during familiarization, we performed 2-photon calcium imaging in mice running in new virtual environments and compared the trial-to-trial dynamics of place cells in CA1 and CA3 over days. We find that place fields in CA1 emerge rapidly but tend to shift backwards from trial-to-trial and remap upon re-exposure to the environment a day later. In contrast, place fields in CA3 emerge gradually but show more stable trial-to-trial and day-to-day dynamics. These results reflect different roles in CA1 and CA3 in spatial memory processing during familiarization to new environments and constrain the potential mechanisms that support them. Nature Publishing Group UK 2021-05-20 /pmc/articles/PMC8137926/ /pubmed/34016996 http://dx.doi.org/10.1038/s41467-021-23260-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Dong, Can
Madar, Antoine D.
Sheffield, Mark E. J.
Distinct place cell dynamics in CA1 and CA3 encode experience in new environments
title Distinct place cell dynamics in CA1 and CA3 encode experience in new environments
title_full Distinct place cell dynamics in CA1 and CA3 encode experience in new environments
title_fullStr Distinct place cell dynamics in CA1 and CA3 encode experience in new environments
title_full_unstemmed Distinct place cell dynamics in CA1 and CA3 encode experience in new environments
title_short Distinct place cell dynamics in CA1 and CA3 encode experience in new environments
title_sort distinct place cell dynamics in ca1 and ca3 encode experience in new environments
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137926/
https://www.ncbi.nlm.nih.gov/pubmed/34016996
http://dx.doi.org/10.1038/s41467-021-23260-3
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