The Role of Ferroptosis in Acute Respiratory Distress Syndrome

Ferroptosis is a newly discovered type of regulated cell death that is different from apoptosis, necrosis and autophagy. Ferroptosis is characterized by iron-dependent lipid peroxidation, which induces cell death. Iron, lipid and amino acid metabolism is associated with ferroptosis. Ferroptosis is i...

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Autores principales: Qu, Mengdi, Zhang, Hao, Chen, Zhaoyuan, Sun, Xingfeng, Zhu, Shuainan, Nan, Ke, Chen, Wankun, Miao, Changhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137978/
https://www.ncbi.nlm.nih.gov/pubmed/34026785
http://dx.doi.org/10.3389/fmed.2021.651552
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author Qu, Mengdi
Zhang, Hao
Chen, Zhaoyuan
Sun, Xingfeng
Zhu, Shuainan
Nan, Ke
Chen, Wankun
Miao, Changhong
author_facet Qu, Mengdi
Zhang, Hao
Chen, Zhaoyuan
Sun, Xingfeng
Zhu, Shuainan
Nan, Ke
Chen, Wankun
Miao, Changhong
author_sort Qu, Mengdi
collection PubMed
description Ferroptosis is a newly discovered type of regulated cell death that is different from apoptosis, necrosis and autophagy. Ferroptosis is characterized by iron-dependent lipid peroxidation, which induces cell death. Iron, lipid and amino acid metabolism is associated with ferroptosis. Ferroptosis is involved in the pathological development of various diseases, such as neurological diseases and cancer. Recent studies have shown that ferroptosis is also closely related to acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS), suggesting that it can be a novel therapeutic target. This article mainly introduces the metabolic mechanism related to ferroptosis and discusses its role in ALI/ARDS to provide new ideas for the treatment of these diseases.
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spelling pubmed-81379782021-05-22 The Role of Ferroptosis in Acute Respiratory Distress Syndrome Qu, Mengdi Zhang, Hao Chen, Zhaoyuan Sun, Xingfeng Zhu, Shuainan Nan, Ke Chen, Wankun Miao, Changhong Front Med (Lausanne) Medicine Ferroptosis is a newly discovered type of regulated cell death that is different from apoptosis, necrosis and autophagy. Ferroptosis is characterized by iron-dependent lipid peroxidation, which induces cell death. Iron, lipid and amino acid metabolism is associated with ferroptosis. Ferroptosis is involved in the pathological development of various diseases, such as neurological diseases and cancer. Recent studies have shown that ferroptosis is also closely related to acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS), suggesting that it can be a novel therapeutic target. This article mainly introduces the metabolic mechanism related to ferroptosis and discusses its role in ALI/ARDS to provide new ideas for the treatment of these diseases. Frontiers Media S.A. 2021-05-07 /pmc/articles/PMC8137978/ /pubmed/34026785 http://dx.doi.org/10.3389/fmed.2021.651552 Text en Copyright © 2021 Qu, Zhang, Chen, Sun, Zhu, Nan, Chen and Miao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Qu, Mengdi
Zhang, Hao
Chen, Zhaoyuan
Sun, Xingfeng
Zhu, Shuainan
Nan, Ke
Chen, Wankun
Miao, Changhong
The Role of Ferroptosis in Acute Respiratory Distress Syndrome
title The Role of Ferroptosis in Acute Respiratory Distress Syndrome
title_full The Role of Ferroptosis in Acute Respiratory Distress Syndrome
title_fullStr The Role of Ferroptosis in Acute Respiratory Distress Syndrome
title_full_unstemmed The Role of Ferroptosis in Acute Respiratory Distress Syndrome
title_short The Role of Ferroptosis in Acute Respiratory Distress Syndrome
title_sort role of ferroptosis in acute respiratory distress syndrome
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137978/
https://www.ncbi.nlm.nih.gov/pubmed/34026785
http://dx.doi.org/10.3389/fmed.2021.651552
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