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Frailty transitions and cognitive function among South Korean older adults

Frailty is considered a multidimensional geriatric syndrome, manifested by the accumulation of age-associated deficits. The consequences of frailty transitions are still understudied. This study evaluated the influence of frailty transitions on cognitive function in the older adult population. We us...

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Autores principales: Nari, Fatima, Jang, Bich Na, Youn, Hin Moi, Jeong, Wonjeong, Jang, Sung-In, Park, Eun-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138002/
https://www.ncbi.nlm.nih.gov/pubmed/34017031
http://dx.doi.org/10.1038/s41598-021-90125-6
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author Nari, Fatima
Jang, Bich Na
Youn, Hin Moi
Jeong, Wonjeong
Jang, Sung-In
Park, Eun-Cheol
author_facet Nari, Fatima
Jang, Bich Na
Youn, Hin Moi
Jeong, Wonjeong
Jang, Sung-In
Park, Eun-Cheol
author_sort Nari, Fatima
collection PubMed
description Frailty is considered a multidimensional geriatric syndrome, manifested by the accumulation of age-associated deficits. The consequences of frailty transitions are still understudied. This study evaluated the influence of frailty transitions on cognitive function in the older adult population. We used data derived from the Korean Longitudinal Study of Aging (KLoSA) (2008–2018) on older adults aged ≥ 65 years. Frailty was assessed using a validated Korean frailty measure known as the frailty instrument (FI), and cognitive function was measured using the Korean version of the Mini-Mental State Examination (K-MMSE). Transitions in frailty and their relationship with cognitive function were investigated using lagged generalized estimating equations (GEE), t-tests, and ANOVA. Respondents who experienced frailty transitions (those with ameliorating frailty), those who developed frailty, and whose frailty remained constant, were more likely to have a lower cognitive function than those who were consistently non-frail. Older age, activities of daily living (ADL) disability, and instrumental ADL disability were more negatively associated with declining cognitive function, especially in the “frail → frail” group. Changes in all individual components of the frailty instrument were significantly associated with impaired cognitive function. The results suggest an association between frailty transitions and cognitive impairment. Over a 2-year span, the remaining frail individuals had the highest rate of cognitive decline in men, while the change from non-frail to frail state in women was significantly associated with the lowest cognitive function values. We recommend early interventions and prevention strategies in older adults to help ameliorate or slow down both frailty and cognitive function decline.
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spelling pubmed-81380022021-05-25 Frailty transitions and cognitive function among South Korean older adults Nari, Fatima Jang, Bich Na Youn, Hin Moi Jeong, Wonjeong Jang, Sung-In Park, Eun-Cheol Sci Rep Article Frailty is considered a multidimensional geriatric syndrome, manifested by the accumulation of age-associated deficits. The consequences of frailty transitions are still understudied. This study evaluated the influence of frailty transitions on cognitive function in the older adult population. We used data derived from the Korean Longitudinal Study of Aging (KLoSA) (2008–2018) on older adults aged ≥ 65 years. Frailty was assessed using a validated Korean frailty measure known as the frailty instrument (FI), and cognitive function was measured using the Korean version of the Mini-Mental State Examination (K-MMSE). Transitions in frailty and their relationship with cognitive function were investigated using lagged generalized estimating equations (GEE), t-tests, and ANOVA. Respondents who experienced frailty transitions (those with ameliorating frailty), those who developed frailty, and whose frailty remained constant, were more likely to have a lower cognitive function than those who were consistently non-frail. Older age, activities of daily living (ADL) disability, and instrumental ADL disability were more negatively associated with declining cognitive function, especially in the “frail → frail” group. Changes in all individual components of the frailty instrument were significantly associated with impaired cognitive function. The results suggest an association between frailty transitions and cognitive impairment. Over a 2-year span, the remaining frail individuals had the highest rate of cognitive decline in men, while the change from non-frail to frail state in women was significantly associated with the lowest cognitive function values. We recommend early interventions and prevention strategies in older adults to help ameliorate or slow down both frailty and cognitive function decline. Nature Publishing Group UK 2021-05-20 /pmc/articles/PMC8138002/ /pubmed/34017031 http://dx.doi.org/10.1038/s41598-021-90125-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nari, Fatima
Jang, Bich Na
Youn, Hin Moi
Jeong, Wonjeong
Jang, Sung-In
Park, Eun-Cheol
Frailty transitions and cognitive function among South Korean older adults
title Frailty transitions and cognitive function among South Korean older adults
title_full Frailty transitions and cognitive function among South Korean older adults
title_fullStr Frailty transitions and cognitive function among South Korean older adults
title_full_unstemmed Frailty transitions and cognitive function among South Korean older adults
title_short Frailty transitions and cognitive function among South Korean older adults
title_sort frailty transitions and cognitive function among south korean older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138002/
https://www.ncbi.nlm.nih.gov/pubmed/34017031
http://dx.doi.org/10.1038/s41598-021-90125-6
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