Wnt signaling in lung development, regeneration, and disease progression

The respiratory tract is a vital, intricate system for several important biological processes including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling pathway plays several crucial and indispensable roles across lung biology in multiple contexts. This review highlight...

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Autores principales: Aros, Cody J., Pantoja, Carla J., Gomperts, Brigitte N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138018/
https://www.ncbi.nlm.nih.gov/pubmed/34017045
http://dx.doi.org/10.1038/s42003-021-02118-w
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author Aros, Cody J.
Pantoja, Carla J.
Gomperts, Brigitte N.
author_facet Aros, Cody J.
Pantoja, Carla J.
Gomperts, Brigitte N.
author_sort Aros, Cody J.
collection PubMed
description The respiratory tract is a vital, intricate system for several important biological processes including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling pathway plays several crucial and indispensable roles across lung biology in multiple contexts. This review highlights the progress made in characterizing the role of Wnt signaling across several disciplines in lung biology, including development, homeostasis, regeneration following injury, in vitro directed differentiation efforts, and disease progression. We further note uncharted directions in the field that may illuminate important biology. The discoveries made collectively advance our understanding of Wnt signaling in lung biology and have the potential to inform therapeutic advancements for lung diseases.
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spelling pubmed-81380182021-06-03 Wnt signaling in lung development, regeneration, and disease progression Aros, Cody J. Pantoja, Carla J. Gomperts, Brigitte N. Commun Biol Review Article The respiratory tract is a vital, intricate system for several important biological processes including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling pathway plays several crucial and indispensable roles across lung biology in multiple contexts. This review highlights the progress made in characterizing the role of Wnt signaling across several disciplines in lung biology, including development, homeostasis, regeneration following injury, in vitro directed differentiation efforts, and disease progression. We further note uncharted directions in the field that may illuminate important biology. The discoveries made collectively advance our understanding of Wnt signaling in lung biology and have the potential to inform therapeutic advancements for lung diseases. Nature Publishing Group UK 2021-05-20 /pmc/articles/PMC8138018/ /pubmed/34017045 http://dx.doi.org/10.1038/s42003-021-02118-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Aros, Cody J.
Pantoja, Carla J.
Gomperts, Brigitte N.
Wnt signaling in lung development, regeneration, and disease progression
title Wnt signaling in lung development, regeneration, and disease progression
title_full Wnt signaling in lung development, regeneration, and disease progression
title_fullStr Wnt signaling in lung development, regeneration, and disease progression
title_full_unstemmed Wnt signaling in lung development, regeneration, and disease progression
title_short Wnt signaling in lung development, regeneration, and disease progression
title_sort wnt signaling in lung development, regeneration, and disease progression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138018/
https://www.ncbi.nlm.nih.gov/pubmed/34017045
http://dx.doi.org/10.1038/s42003-021-02118-w
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