Cargando…

Genetic architecture and lifetime dynamics of inbreeding depression in a wild mammal

Inbreeding depression is ubiquitous, but we still know little about its genetic architecture and precise effects in wild populations. Here, we combine long-term life-history data with 417 K imputed SNP genotypes for 5952 wild Soay sheep to explore inbreeding depression on a key fitness component, an...

Descripción completa

Detalles Bibliográficos
Autores principales: Stoffel, M. A., Johnston, S. E., Pilkington, J. G., Pemberton, J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138023/
https://www.ncbi.nlm.nih.gov/pubmed/34016997
http://dx.doi.org/10.1038/s41467-021-23222-9
_version_ 1783695725544079360
author Stoffel, M. A.
Johnston, S. E.
Pilkington, J. G.
Pemberton, J. M.
author_facet Stoffel, M. A.
Johnston, S. E.
Pilkington, J. G.
Pemberton, J. M.
author_sort Stoffel, M. A.
collection PubMed
description Inbreeding depression is ubiquitous, but we still know little about its genetic architecture and precise effects in wild populations. Here, we combine long-term life-history data with 417 K imputed SNP genotypes for 5952 wild Soay sheep to explore inbreeding depression on a key fitness component, annual survival. Inbreeding manifests in long runs of homozygosity (ROH), which make up nearly half of the genome in the most inbred individuals. The ROH landscape varies widely across the genome, with islands where up to 87% and deserts where only 4% of individuals have ROH. The fitness consequences of inbreeding are severe; a 10% increase in individual inbreeding F(ROH) is associated with a 60% reduction in the odds of survival in lambs, though inbreeding depression decreases with age. Finally, a genome-wide association scan on ROH shows that many loci with small effects and five loci with larger effects contribute to inbreeding depression in survival.
format Online
Article
Text
id pubmed-8138023
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-81380232021-06-03 Genetic architecture and lifetime dynamics of inbreeding depression in a wild mammal Stoffel, M. A. Johnston, S. E. Pilkington, J. G. Pemberton, J. M. Nat Commun Article Inbreeding depression is ubiquitous, but we still know little about its genetic architecture and precise effects in wild populations. Here, we combine long-term life-history data with 417 K imputed SNP genotypes for 5952 wild Soay sheep to explore inbreeding depression on a key fitness component, annual survival. Inbreeding manifests in long runs of homozygosity (ROH), which make up nearly half of the genome in the most inbred individuals. The ROH landscape varies widely across the genome, with islands where up to 87% and deserts where only 4% of individuals have ROH. The fitness consequences of inbreeding are severe; a 10% increase in individual inbreeding F(ROH) is associated with a 60% reduction in the odds of survival in lambs, though inbreeding depression decreases with age. Finally, a genome-wide association scan on ROH shows that many loci with small effects and five loci with larger effects contribute to inbreeding depression in survival. Nature Publishing Group UK 2021-05-20 /pmc/articles/PMC8138023/ /pubmed/34016997 http://dx.doi.org/10.1038/s41467-021-23222-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Stoffel, M. A.
Johnston, S. E.
Pilkington, J. G.
Pemberton, J. M.
Genetic architecture and lifetime dynamics of inbreeding depression in a wild mammal
title Genetic architecture and lifetime dynamics of inbreeding depression in a wild mammal
title_full Genetic architecture and lifetime dynamics of inbreeding depression in a wild mammal
title_fullStr Genetic architecture and lifetime dynamics of inbreeding depression in a wild mammal
title_full_unstemmed Genetic architecture and lifetime dynamics of inbreeding depression in a wild mammal
title_short Genetic architecture and lifetime dynamics of inbreeding depression in a wild mammal
title_sort genetic architecture and lifetime dynamics of inbreeding depression in a wild mammal
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138023/
https://www.ncbi.nlm.nih.gov/pubmed/34016997
http://dx.doi.org/10.1038/s41467-021-23222-9
work_keys_str_mv AT stoffelma geneticarchitectureandlifetimedynamicsofinbreedingdepressioninawildmammal
AT johnstonse geneticarchitectureandlifetimedynamicsofinbreedingdepressioninawildmammal
AT pilkingtonjg geneticarchitectureandlifetimedynamicsofinbreedingdepressioninawildmammal
AT pembertonjm geneticarchitectureandlifetimedynamicsofinbreedingdepressioninawildmammal