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Cellular and Molecular Mechanisms of Pristimerin in Cancer Therapy: Recent Advances

Seeking an efficient and safe approach to eliminate tumors is a common goal of medical fields. Over these years, traditional Chinese medicine has attracted growing attention in cancer treatment due to its long history. Pristimerin is a naturally occurring quinone methide triterpenoid used in traditi...

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Autores principales: Chen, Run-Ze, Yang, Fei, Zhang, Min, Sun, Zhi-Gang, Zhang, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138054/
https://www.ncbi.nlm.nih.gov/pubmed/34026649
http://dx.doi.org/10.3389/fonc.2021.671548
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author Chen, Run-Ze
Yang, Fei
Zhang, Min
Sun, Zhi-Gang
Zhang, Nan
author_facet Chen, Run-Ze
Yang, Fei
Zhang, Min
Sun, Zhi-Gang
Zhang, Nan
author_sort Chen, Run-Ze
collection PubMed
description Seeking an efficient and safe approach to eliminate tumors is a common goal of medical fields. Over these years, traditional Chinese medicine has attracted growing attention in cancer treatment due to its long history. Pristimerin is a naturally occurring quinone methide triterpenoid used in traditional Chinese medicine to treat various cancers. Recent studies have identified alterations in cellular events and molecular signaling targets of cancer cells under pristimerin treatment. Pristimerin induces cell cycle arrest, apoptosis, and autophagy to exhibit anti-proliferation effects against tumors. Pristimerin also inhibits the invasion, migration, and metastasis of tumor cells via affecting cell adhesion, cytoskeleton, epithelial-mesenchymal transition, cancer stem cells, and angiogenesis. Molecular factors and pathways are associated with the anti-cancer activities of pristimerin. Furthermore, pristimerin reverses multidrug resistance of cancer cells and exerts synergizing effects with other chemotherapeutic drugs. This review aims to discuss the anti-cancer potentials of pristimerin, emphasizing multi-targeted biological and molecular regulations in cancers. Further investigations and clinical trials are warranted to understand the advantages and disadvantages of pristimerin treatment much better.
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spelling pubmed-81380542021-05-22 Cellular and Molecular Mechanisms of Pristimerin in Cancer Therapy: Recent Advances Chen, Run-Ze Yang, Fei Zhang, Min Sun, Zhi-Gang Zhang, Nan Front Oncol Oncology Seeking an efficient and safe approach to eliminate tumors is a common goal of medical fields. Over these years, traditional Chinese medicine has attracted growing attention in cancer treatment due to its long history. Pristimerin is a naturally occurring quinone methide triterpenoid used in traditional Chinese medicine to treat various cancers. Recent studies have identified alterations in cellular events and molecular signaling targets of cancer cells under pristimerin treatment. Pristimerin induces cell cycle arrest, apoptosis, and autophagy to exhibit anti-proliferation effects against tumors. Pristimerin also inhibits the invasion, migration, and metastasis of tumor cells via affecting cell adhesion, cytoskeleton, epithelial-mesenchymal transition, cancer stem cells, and angiogenesis. Molecular factors and pathways are associated with the anti-cancer activities of pristimerin. Furthermore, pristimerin reverses multidrug resistance of cancer cells and exerts synergizing effects with other chemotherapeutic drugs. This review aims to discuss the anti-cancer potentials of pristimerin, emphasizing multi-targeted biological and molecular regulations in cancers. Further investigations and clinical trials are warranted to understand the advantages and disadvantages of pristimerin treatment much better. Frontiers Media S.A. 2021-05-07 /pmc/articles/PMC8138054/ /pubmed/34026649 http://dx.doi.org/10.3389/fonc.2021.671548 Text en Copyright © 2021 Chen, Yang, Zhang, Sun and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Run-Ze
Yang, Fei
Zhang, Min
Sun, Zhi-Gang
Zhang, Nan
Cellular and Molecular Mechanisms of Pristimerin in Cancer Therapy: Recent Advances
title Cellular and Molecular Mechanisms of Pristimerin in Cancer Therapy: Recent Advances
title_full Cellular and Molecular Mechanisms of Pristimerin in Cancer Therapy: Recent Advances
title_fullStr Cellular and Molecular Mechanisms of Pristimerin in Cancer Therapy: Recent Advances
title_full_unstemmed Cellular and Molecular Mechanisms of Pristimerin in Cancer Therapy: Recent Advances
title_short Cellular and Molecular Mechanisms of Pristimerin in Cancer Therapy: Recent Advances
title_sort cellular and molecular mechanisms of pristimerin in cancer therapy: recent advances
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138054/
https://www.ncbi.nlm.nih.gov/pubmed/34026649
http://dx.doi.org/10.3389/fonc.2021.671548
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