Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure

Mitofusin 2 (Mfn2) is a transmembrane GTPase located on the mitochondrial outer membrane that contributes to mitochondrial network regulation. It is an essential multifunctional protein that participates in various biological processes under physical and pathological conditions, including mitochondr...

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Autores principales: Chen, Lei, Liu, Bilin, Qin, Yuan, Li, Anqi, Gao, Meng, Liu, Hanyu, Gong, Guohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138128/
https://www.ncbi.nlm.nih.gov/pubmed/34026850
http://dx.doi.org/10.3389/fmolb.2021.681237
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author Chen, Lei
Liu, Bilin
Qin, Yuan
Li, Anqi
Gao, Meng
Liu, Hanyu
Gong, Guohua
author_facet Chen, Lei
Liu, Bilin
Qin, Yuan
Li, Anqi
Gao, Meng
Liu, Hanyu
Gong, Guohua
author_sort Chen, Lei
collection PubMed
description Mitofusin 2 (Mfn2) is a transmembrane GTPase located on the mitochondrial outer membrane that contributes to mitochondrial network regulation. It is an essential multifunctional protein that participates in various biological processes under physical and pathological conditions, including mitochondrial fusion, reticulum–mitochondria contacts, mitochondrial quality control, and apoptosis. Mfn2 dysfunctions have been found to contribute to cardiovascular diseases, such as ischemia-reperfusion injury, heart failure, and dilated cardiomyopathy. Here, this review mainly focuses on what is known about the structure and function of Mfn2 and its crucial role in heart failure.
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spelling pubmed-81381282021-05-22 Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure Chen, Lei Liu, Bilin Qin, Yuan Li, Anqi Gao, Meng Liu, Hanyu Gong, Guohua Front Mol Biosci Molecular Biosciences Mitofusin 2 (Mfn2) is a transmembrane GTPase located on the mitochondrial outer membrane that contributes to mitochondrial network regulation. It is an essential multifunctional protein that participates in various biological processes under physical and pathological conditions, including mitochondrial fusion, reticulum–mitochondria contacts, mitochondrial quality control, and apoptosis. Mfn2 dysfunctions have been found to contribute to cardiovascular diseases, such as ischemia-reperfusion injury, heart failure, and dilated cardiomyopathy. Here, this review mainly focuses on what is known about the structure and function of Mfn2 and its crucial role in heart failure. Frontiers Media S.A. 2021-05-07 /pmc/articles/PMC8138128/ /pubmed/34026850 http://dx.doi.org/10.3389/fmolb.2021.681237 Text en Copyright © 2021 Chen, Liu, Qin, Li, Gao, Liu and Gong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Chen, Lei
Liu, Bilin
Qin, Yuan
Li, Anqi
Gao, Meng
Liu, Hanyu
Gong, Guohua
Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure
title Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure
title_full Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure
title_fullStr Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure
title_full_unstemmed Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure
title_short Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure
title_sort mitochondrial fusion protein mfn2 and its role in heart failure
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138128/
https://www.ncbi.nlm.nih.gov/pubmed/34026850
http://dx.doi.org/10.3389/fmolb.2021.681237
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