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Etiology of Dementia in Thai Patients
INTRODUCTION: Molecular imaging has been developed and validated in Thai patients, comprising a portion of patients in the dementia registry. This should provide a more accurate diagnosis of the etiology of dementia, which was the focus of this study. METHODS: This was a multicenter dementia study....
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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S. Karger AG
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138237/ https://www.ncbi.nlm.nih.gov/pubmed/34054910 http://dx.doi.org/10.1159/000515676 |
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author | Dharmasaroja, Pornpatr A. Assanasen, Jintana Pongpakdee, Sunsanee Jaisin, Kankamol Lolekha, Praween Phanasathit, Muthita Cheewakriengkrai, Laksanun Chotipanich, Chanisa Witoonpanich, Pirada Pitiyarn, Sutisa Lertwilaiwittaya, Pongtawat Dejthevaporn, Charungthai Limwongse, Chanin Phanthumchinda, Kammant |
author_facet | Dharmasaroja, Pornpatr A. Assanasen, Jintana Pongpakdee, Sunsanee Jaisin, Kankamol Lolekha, Praween Phanasathit, Muthita Cheewakriengkrai, Laksanun Chotipanich, Chanisa Witoonpanich, Pirada Pitiyarn, Sutisa Lertwilaiwittaya, Pongtawat Dejthevaporn, Charungthai Limwongse, Chanin Phanthumchinda, Kammant |
author_sort | Dharmasaroja, Pornpatr A. |
collection | PubMed |
description | INTRODUCTION: Molecular imaging has been developed and validated in Thai patients, comprising a portion of patients in the dementia registry. This should provide a more accurate diagnosis of the etiology of dementia, which was the focus of this study. METHODS: This was a multicenter dementia study. The baseline characteristics, main presenting symptoms, and results of investigations and cognitive tests of the patients were electronically collected in the registry. Functional imaging and/or molecular imaging were performed in patients with an equivocal diagnosis of the causes of dementia, especially in atypical dementia or young onset dementia (YOD). RESULTS: There were 454 patients in the study. The mean age of the patients was 78 years, with 60% female. Functional imaging and/or molecular imaging were performed in 57 patients (57/454 patients, 13%). The most common cause of dementia was Alzheimer's disease (AD; 50%), followed by vascular dementia (VAD; 24%), dementia with Lewy bodies (6%), Parkinson's disease dementia (6%), frontotemporal dementia (FTD; 2.6%), progressive supranuclear palsy (2%), multiple system atrophy (0.8%), and corticobasal syndrome (0.4%). YOD accounted for 17% (77/454 patients), with a mean age of 58 years. The causes of YOD were early onset amnestic AD (44%), VAD (16%), behavioral variant FTD (8%), posterior cortical atrophy (6.5%), and logopenic variant primary progressive aphasia (5.2%). CONCLUSION: AD was the most common cause of dementia in Thai patients and the distribution of other types of dementia and main presenting symptoms were similar to previous reports in Western patients; however, the proportion of YOD was higher. |
format | Online Article Text |
id | pubmed-8138237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-81382372021-05-27 Etiology of Dementia in Thai Patients Dharmasaroja, Pornpatr A. Assanasen, Jintana Pongpakdee, Sunsanee Jaisin, Kankamol Lolekha, Praween Phanasathit, Muthita Cheewakriengkrai, Laksanun Chotipanich, Chanisa Witoonpanich, Pirada Pitiyarn, Sutisa Lertwilaiwittaya, Pongtawat Dejthevaporn, Charungthai Limwongse, Chanin Phanthumchinda, Kammant Dement Geriatr Cogn Dis Extra Research Article INTRODUCTION: Molecular imaging has been developed and validated in Thai patients, comprising a portion of patients in the dementia registry. This should provide a more accurate diagnosis of the etiology of dementia, which was the focus of this study. METHODS: This was a multicenter dementia study. The baseline characteristics, main presenting symptoms, and results of investigations and cognitive tests of the patients were electronically collected in the registry. Functional imaging and/or molecular imaging were performed in patients with an equivocal diagnosis of the causes of dementia, especially in atypical dementia or young onset dementia (YOD). RESULTS: There were 454 patients in the study. The mean age of the patients was 78 years, with 60% female. Functional imaging and/or molecular imaging were performed in 57 patients (57/454 patients, 13%). The most common cause of dementia was Alzheimer's disease (AD; 50%), followed by vascular dementia (VAD; 24%), dementia with Lewy bodies (6%), Parkinson's disease dementia (6%), frontotemporal dementia (FTD; 2.6%), progressive supranuclear palsy (2%), multiple system atrophy (0.8%), and corticobasal syndrome (0.4%). YOD accounted for 17% (77/454 patients), with a mean age of 58 years. The causes of YOD were early onset amnestic AD (44%), VAD (16%), behavioral variant FTD (8%), posterior cortical atrophy (6.5%), and logopenic variant primary progressive aphasia (5.2%). CONCLUSION: AD was the most common cause of dementia in Thai patients and the distribution of other types of dementia and main presenting symptoms were similar to previous reports in Western patients; however, the proportion of YOD was higher. S. Karger AG 2021-04-15 /pmc/articles/PMC8138237/ /pubmed/34054910 http://dx.doi.org/10.1159/000515676 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc-nd/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. |
spellingShingle | Research Article Dharmasaroja, Pornpatr A. Assanasen, Jintana Pongpakdee, Sunsanee Jaisin, Kankamol Lolekha, Praween Phanasathit, Muthita Cheewakriengkrai, Laksanun Chotipanich, Chanisa Witoonpanich, Pirada Pitiyarn, Sutisa Lertwilaiwittaya, Pongtawat Dejthevaporn, Charungthai Limwongse, Chanin Phanthumchinda, Kammant Etiology of Dementia in Thai Patients |
title | Etiology of Dementia in Thai Patients |
title_full | Etiology of Dementia in Thai Patients |
title_fullStr | Etiology of Dementia in Thai Patients |
title_full_unstemmed | Etiology of Dementia in Thai Patients |
title_short | Etiology of Dementia in Thai Patients |
title_sort | etiology of dementia in thai patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138237/ https://www.ncbi.nlm.nih.gov/pubmed/34054910 http://dx.doi.org/10.1159/000515676 |
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