Cargando…
Successful Treatment of Relapsed/Refractory Extramedullary Multiple Myeloma With Anti-BCMA CAR-T Cell Therapy Followed by Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report and a Review of the Contemporary Literature
Extramedullary multiple myeloma (EMM) is an aggressive sub-entity of multiple myeloma (MM). Despite an excellent improvement in survival for most patients with MM over recent decades, the overall survival (OS) of patients with EMM was usually not longer than 3 years. Standard treatment for patients...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138324/ https://www.ncbi.nlm.nih.gov/pubmed/34026784 http://dx.doi.org/10.3389/fmed.2021.649824 |
_version_ | 1783695782253166592 |
---|---|
author | Qian, Ying Qian, Zijun Zhao, Xiujie Pan, Wenjue Wei, Xinzheng Meng, Huimin Yang, Lin Xiao, Haowen |
author_facet | Qian, Ying Qian, Zijun Zhao, Xiujie Pan, Wenjue Wei, Xinzheng Meng, Huimin Yang, Lin Xiao, Haowen |
author_sort | Qian, Ying |
collection | PubMed |
description | Extramedullary multiple myeloma (EMM) is an aggressive sub-entity of multiple myeloma (MM). Despite an excellent improvement in survival for most patients with MM over recent decades, the overall survival (OS) of patients with EMM was usually not longer than 3 years. Standard treatment for patients with EMM has not been established, and their management is particularly challenging. We presented a heavily pretreated young patient with relapsed EMM and refractoriness to a proteasome inhibitor (PI; bortezomib), a next-generation PI (ixazomib), immunomodulatory drugs (IMiDs; lenalidomide), autologous hematopoietic stem cell transplantation (ASCT), and monoclonal antibody (directed against CD38: daratumumab) and indicated that myeloablative haploidentical hematopoietic stem cell transplantation (haploidentical-HSCT) as a salvage treatment of relapse after a chimeric antigen receptor (CAR)-T cell therapy that targeted B-cell maturation antigen (BCMA) (NCT04650724) is feasible. Taken together of the contemporary literature, the promising results on the effect of anti-BCMA CAR-T cell therapy and allogeneic HSCT might present a proof-of-principle for patients with EMM, and therefore, patients with the disease need to be included in future studies. |
format | Online Article Text |
id | pubmed-8138324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81383242021-05-22 Successful Treatment of Relapsed/Refractory Extramedullary Multiple Myeloma With Anti-BCMA CAR-T Cell Therapy Followed by Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report and a Review of the Contemporary Literature Qian, Ying Qian, Zijun Zhao, Xiujie Pan, Wenjue Wei, Xinzheng Meng, Huimin Yang, Lin Xiao, Haowen Front Med (Lausanne) Medicine Extramedullary multiple myeloma (EMM) is an aggressive sub-entity of multiple myeloma (MM). Despite an excellent improvement in survival for most patients with MM over recent decades, the overall survival (OS) of patients with EMM was usually not longer than 3 years. Standard treatment for patients with EMM has not been established, and their management is particularly challenging. We presented a heavily pretreated young patient with relapsed EMM and refractoriness to a proteasome inhibitor (PI; bortezomib), a next-generation PI (ixazomib), immunomodulatory drugs (IMiDs; lenalidomide), autologous hematopoietic stem cell transplantation (ASCT), and monoclonal antibody (directed against CD38: daratumumab) and indicated that myeloablative haploidentical hematopoietic stem cell transplantation (haploidentical-HSCT) as a salvage treatment of relapse after a chimeric antigen receptor (CAR)-T cell therapy that targeted B-cell maturation antigen (BCMA) (NCT04650724) is feasible. Taken together of the contemporary literature, the promising results on the effect of anti-BCMA CAR-T cell therapy and allogeneic HSCT might present a proof-of-principle for patients with EMM, and therefore, patients with the disease need to be included in future studies. Frontiers Media S.A. 2021-05-07 /pmc/articles/PMC8138324/ /pubmed/34026784 http://dx.doi.org/10.3389/fmed.2021.649824 Text en Copyright © 2021 Qian, Qian, Zhao, Pan, Wei, Meng, Yang and Xiao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Qian, Ying Qian, Zijun Zhao, Xiujie Pan, Wenjue Wei, Xinzheng Meng, Huimin Yang, Lin Xiao, Haowen Successful Treatment of Relapsed/Refractory Extramedullary Multiple Myeloma With Anti-BCMA CAR-T Cell Therapy Followed by Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report and a Review of the Contemporary Literature |
title | Successful Treatment of Relapsed/Refractory Extramedullary Multiple Myeloma With Anti-BCMA CAR-T Cell Therapy Followed by Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report and a Review of the Contemporary Literature |
title_full | Successful Treatment of Relapsed/Refractory Extramedullary Multiple Myeloma With Anti-BCMA CAR-T Cell Therapy Followed by Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report and a Review of the Contemporary Literature |
title_fullStr | Successful Treatment of Relapsed/Refractory Extramedullary Multiple Myeloma With Anti-BCMA CAR-T Cell Therapy Followed by Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report and a Review of the Contemporary Literature |
title_full_unstemmed | Successful Treatment of Relapsed/Refractory Extramedullary Multiple Myeloma With Anti-BCMA CAR-T Cell Therapy Followed by Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report and a Review of the Contemporary Literature |
title_short | Successful Treatment of Relapsed/Refractory Extramedullary Multiple Myeloma With Anti-BCMA CAR-T Cell Therapy Followed by Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report and a Review of the Contemporary Literature |
title_sort | successful treatment of relapsed/refractory extramedullary multiple myeloma with anti-bcma car-t cell therapy followed by haploidentical hematopoietic stem cell transplantation: a case report and a review of the contemporary literature |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138324/ https://www.ncbi.nlm.nih.gov/pubmed/34026784 http://dx.doi.org/10.3389/fmed.2021.649824 |
work_keys_str_mv | AT qianying successfultreatmentofrelapsedrefractoryextramedullarymultiplemyelomawithantibcmacartcelltherapyfollowedbyhaploidenticalhematopoieticstemcelltransplantationacasereportandareviewofthecontemporaryliterature AT qianzijun successfultreatmentofrelapsedrefractoryextramedullarymultiplemyelomawithantibcmacartcelltherapyfollowedbyhaploidenticalhematopoieticstemcelltransplantationacasereportandareviewofthecontemporaryliterature AT zhaoxiujie successfultreatmentofrelapsedrefractoryextramedullarymultiplemyelomawithantibcmacartcelltherapyfollowedbyhaploidenticalhematopoieticstemcelltransplantationacasereportandareviewofthecontemporaryliterature AT panwenjue successfultreatmentofrelapsedrefractoryextramedullarymultiplemyelomawithantibcmacartcelltherapyfollowedbyhaploidenticalhematopoieticstemcelltransplantationacasereportandareviewofthecontemporaryliterature AT weixinzheng successfultreatmentofrelapsedrefractoryextramedullarymultiplemyelomawithantibcmacartcelltherapyfollowedbyhaploidenticalhematopoieticstemcelltransplantationacasereportandareviewofthecontemporaryliterature AT menghuimin successfultreatmentofrelapsedrefractoryextramedullarymultiplemyelomawithantibcmacartcelltherapyfollowedbyhaploidenticalhematopoieticstemcelltransplantationacasereportandareviewofthecontemporaryliterature AT yanglin successfultreatmentofrelapsedrefractoryextramedullarymultiplemyelomawithantibcmacartcelltherapyfollowedbyhaploidenticalhematopoieticstemcelltransplantationacasereportandareviewofthecontemporaryliterature AT xiaohaowen successfultreatmentofrelapsedrefractoryextramedullarymultiplemyelomawithantibcmacartcelltherapyfollowedbyhaploidenticalhematopoieticstemcelltransplantationacasereportandareviewofthecontemporaryliterature |