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Hemorrhagic manifestation in different etiologies of pancytopenia: A prospective, cross-sectional study

BACKGROUND: Pancytopenia is a triage of anemia, leukopenia, and thrombocytopenia. The etiology causing pancytopenia varies depending upon factors such as age, sex, occupation, and geographical distribution. Unfortunately, the major treatises of hematology have not given emphasis on the hemorrhagic m...

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Autores principales: Singh, Mridu, Singh, Vikram, Singh, Durga Prasad, Bohra, Gopal Krishna, Misra, Arup Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138370/
https://www.ncbi.nlm.nih.gov/pubmed/34041080
http://dx.doi.org/10.4103/jfmpc.jfmpc_1117_20
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author Singh, Mridu
Singh, Vikram
Singh, Durga Prasad
Bohra, Gopal Krishna
Misra, Arup Kumar
author_facet Singh, Mridu
Singh, Vikram
Singh, Durga Prasad
Bohra, Gopal Krishna
Misra, Arup Kumar
author_sort Singh, Mridu
collection PubMed
description BACKGROUND: Pancytopenia is a triage of anemia, leukopenia, and thrombocytopenia. The etiology causing pancytopenia varies depending upon factors such as age, sex, occupation, and geographical distribution. Unfortunately, the major treatises of hematology have not given emphasis on the hemorrhagic manifestation of different etiologies causing pancytopenia. OBJECTIVE: This observational study was carried out with the aim to identify hemorrhagic manifestation in patients with pancytopenia in eastern India. DESIGN: This study was conducted over a period of two years at the Department of Medicine of a tertiary care teaching institute in eastern India. All the patients with features of anemia, thrombocytopenia, or leukopenia were screened for pancytopenia and a total of 214 cases were selected. Patients were divided into two groups as patients with age more than 14 years constitute group one and the patients less than 14 years constitute the second group. A detailed physical examination, hematological, and biochemical investigation was done to ascertain the hemorrhagic manifestations in pancytopenia patients. RESULTS: In the groups, the most common cause of hemorrhagic manifestation in patients with pancytopenia was aplastic anemic, leukemia, myelodysplastic syndrome, and myelofibrosis. No bleeding manifestation was seen in patients with megaloblastic anemia, kala-azar, hypersplenism, and other causes of pancytopenia. CONCLUSIONS: Patients with pancytopenia caused by aplastic anemia, acute leukemia, and myelodysplastic syndrome have more chances of bleeding manifestation as compared with pancytopenia caused by megaloblastic anemia, kala-azar, or hypersplenism.
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spelling pubmed-81383702021-05-25 Hemorrhagic manifestation in different etiologies of pancytopenia: A prospective, cross-sectional study Singh, Mridu Singh, Vikram Singh, Durga Prasad Bohra, Gopal Krishna Misra, Arup Kumar J Family Med Prim Care Original Article BACKGROUND: Pancytopenia is a triage of anemia, leukopenia, and thrombocytopenia. The etiology causing pancytopenia varies depending upon factors such as age, sex, occupation, and geographical distribution. Unfortunately, the major treatises of hematology have not given emphasis on the hemorrhagic manifestation of different etiologies causing pancytopenia. OBJECTIVE: This observational study was carried out with the aim to identify hemorrhagic manifestation in patients with pancytopenia in eastern India. DESIGN: This study was conducted over a period of two years at the Department of Medicine of a tertiary care teaching institute in eastern India. All the patients with features of anemia, thrombocytopenia, or leukopenia were screened for pancytopenia and a total of 214 cases were selected. Patients were divided into two groups as patients with age more than 14 years constitute group one and the patients less than 14 years constitute the second group. A detailed physical examination, hematological, and biochemical investigation was done to ascertain the hemorrhagic manifestations in pancytopenia patients. RESULTS: In the groups, the most common cause of hemorrhagic manifestation in patients with pancytopenia was aplastic anemic, leukemia, myelodysplastic syndrome, and myelofibrosis. No bleeding manifestation was seen in patients with megaloblastic anemia, kala-azar, hypersplenism, and other causes of pancytopenia. CONCLUSIONS: Patients with pancytopenia caused by aplastic anemia, acute leukemia, and myelodysplastic syndrome have more chances of bleeding manifestation as compared with pancytopenia caused by megaloblastic anemia, kala-azar, or hypersplenism. Wolters Kluwer - Medknow 2021-02 2021-02-27 /pmc/articles/PMC8138370/ /pubmed/34041080 http://dx.doi.org/10.4103/jfmpc.jfmpc_1117_20 Text en Copyright: © 2021 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Singh, Mridu
Singh, Vikram
Singh, Durga Prasad
Bohra, Gopal Krishna
Misra, Arup Kumar
Hemorrhagic manifestation in different etiologies of pancytopenia: A prospective, cross-sectional study
title Hemorrhagic manifestation in different etiologies of pancytopenia: A prospective, cross-sectional study
title_full Hemorrhagic manifestation in different etiologies of pancytopenia: A prospective, cross-sectional study
title_fullStr Hemorrhagic manifestation in different etiologies of pancytopenia: A prospective, cross-sectional study
title_full_unstemmed Hemorrhagic manifestation in different etiologies of pancytopenia: A prospective, cross-sectional study
title_short Hemorrhagic manifestation in different etiologies of pancytopenia: A prospective, cross-sectional study
title_sort hemorrhagic manifestation in different etiologies of pancytopenia: a prospective, cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138370/
https://www.ncbi.nlm.nih.gov/pubmed/34041080
http://dx.doi.org/10.4103/jfmpc.jfmpc_1117_20
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AT bohragopalkrishna hemorrhagicmanifestationindifferentetiologiesofpancytopeniaaprospectivecrosssectionalstudy
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