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Modeling Influencing Factors in B-Cell Reconstitution After Hematopoietic Stem Cell Transplantation in Children

Reduced total and memory B-cell numbers in peripheral blood long term after hematopoietic stem cell transplantation (HSCT) are associated with an increased incidence of infections and immune complications. Using novel modelling strategies, baseline factors influencing B-cell reconstitution can be co...

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Autores principales: van der Maas, Nicolaas G., von Asmuth, Erik G. J., Berghuis, Dagmar, van Schouwenburg, Pauline A., Putter, Hein, van der Burg, Mirjam, Lankester, Arjan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138425/
https://www.ncbi.nlm.nih.gov/pubmed/34025685
http://dx.doi.org/10.3389/fimmu.2021.684147
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author van der Maas, Nicolaas G.
von Asmuth, Erik G. J.
Berghuis, Dagmar
van Schouwenburg, Pauline A.
Putter, Hein
van der Burg, Mirjam
Lankester, Arjan C.
author_facet van der Maas, Nicolaas G.
von Asmuth, Erik G. J.
Berghuis, Dagmar
van Schouwenburg, Pauline A.
Putter, Hein
van der Burg, Mirjam
Lankester, Arjan C.
author_sort van der Maas, Nicolaas G.
collection PubMed
description Reduced total and memory B-cell numbers in peripheral blood long term after hematopoietic stem cell transplantation (HSCT) are associated with an increased incidence of infections and immune complications. Using novel modelling strategies, baseline factors influencing B-cell reconstitution can be comprehensively studied. This study aims to investigate the numerical total and memory B-cell reconstitution in children and the association with baseline determinants 0.5-2 years after allogeneic HSCT. Eligible for inclusion were children transplanted in our center between 2004-2017 who received a first HSCT for malignant or non-malignant disorders. The continuous absolute counts of total and memory B-cells were evaluated as outcome measure. Exploratory analysis at one year was done to identify possible determinants. Linear mixed effect modelling was used to analyze the association of these determinants with total and memory B-cell reconstitution 0.5-2 years after HSCT. In a cohort of 223 evaluable patients analyzed at 1-year after HSCT donor age, stem cell source, donor type, recipient age and conditioning were identified as significant determinants for total and memory B-cell numbers. Multivariable analysis revealed that both donor and recipient age were inversely correlated with the size of total and memory B-cell reconstitution. In contrast, no correlation was found with stem cell source, donor type and conditioning. Making use of linear mixed modelling both stem cell donor and recipient age were identified as independent determinants of total and memory B-cell reconstitution 0.5-2 years after HSCT.
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spelling pubmed-81384252021-05-22 Modeling Influencing Factors in B-Cell Reconstitution After Hematopoietic Stem Cell Transplantation in Children van der Maas, Nicolaas G. von Asmuth, Erik G. J. Berghuis, Dagmar van Schouwenburg, Pauline A. Putter, Hein van der Burg, Mirjam Lankester, Arjan C. Front Immunol Immunology Reduced total and memory B-cell numbers in peripheral blood long term after hematopoietic stem cell transplantation (HSCT) are associated with an increased incidence of infections and immune complications. Using novel modelling strategies, baseline factors influencing B-cell reconstitution can be comprehensively studied. This study aims to investigate the numerical total and memory B-cell reconstitution in children and the association with baseline determinants 0.5-2 years after allogeneic HSCT. Eligible for inclusion were children transplanted in our center between 2004-2017 who received a first HSCT for malignant or non-malignant disorders. The continuous absolute counts of total and memory B-cells were evaluated as outcome measure. Exploratory analysis at one year was done to identify possible determinants. Linear mixed effect modelling was used to analyze the association of these determinants with total and memory B-cell reconstitution 0.5-2 years after HSCT. In a cohort of 223 evaluable patients analyzed at 1-year after HSCT donor age, stem cell source, donor type, recipient age and conditioning were identified as significant determinants for total and memory B-cell numbers. Multivariable analysis revealed that both donor and recipient age were inversely correlated with the size of total and memory B-cell reconstitution. In contrast, no correlation was found with stem cell source, donor type and conditioning. Making use of linear mixed modelling both stem cell donor and recipient age were identified as independent determinants of total and memory B-cell reconstitution 0.5-2 years after HSCT. Frontiers Media S.A. 2021-05-07 /pmc/articles/PMC8138425/ /pubmed/34025685 http://dx.doi.org/10.3389/fimmu.2021.684147 Text en Copyright © 2021 van der Maas, von Asmuth, Berghuis, van Schouwenburg, Putter, van der Burg and Lankester https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
van der Maas, Nicolaas G.
von Asmuth, Erik G. J.
Berghuis, Dagmar
van Schouwenburg, Pauline A.
Putter, Hein
van der Burg, Mirjam
Lankester, Arjan C.
Modeling Influencing Factors in B-Cell Reconstitution After Hematopoietic Stem Cell Transplantation in Children
title Modeling Influencing Factors in B-Cell Reconstitution After Hematopoietic Stem Cell Transplantation in Children
title_full Modeling Influencing Factors in B-Cell Reconstitution After Hematopoietic Stem Cell Transplantation in Children
title_fullStr Modeling Influencing Factors in B-Cell Reconstitution After Hematopoietic Stem Cell Transplantation in Children
title_full_unstemmed Modeling Influencing Factors in B-Cell Reconstitution After Hematopoietic Stem Cell Transplantation in Children
title_short Modeling Influencing Factors in B-Cell Reconstitution After Hematopoietic Stem Cell Transplantation in Children
title_sort modeling influencing factors in b-cell reconstitution after hematopoietic stem cell transplantation in children
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138425/
https://www.ncbi.nlm.nih.gov/pubmed/34025685
http://dx.doi.org/10.3389/fimmu.2021.684147
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