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Curcumin as a Potential Treatment for COVID-19

Coronavirus disease 2019 (COVID-19) is an infectious disease that rapidly spread throughout the world leading to high mortality rates. Despite the knowledge of previous diseases caused by viruses of the same family, such as MERS and SARS-CoV, management and treatment of patients with COVID-19 is a c...

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Autores principales: Rattis, Bruna A. C., Ramos, Simone G., Celes, Mara R. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138567/
https://www.ncbi.nlm.nih.gov/pubmed/34025433
http://dx.doi.org/10.3389/fphar.2021.675287
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author Rattis, Bruna A. C.
Ramos, Simone G.
Celes, Mara R. N.
author_facet Rattis, Bruna A. C.
Ramos, Simone G.
Celes, Mara R. N.
author_sort Rattis, Bruna A. C.
collection PubMed
description Coronavirus disease 2019 (COVID-19) is an infectious disease that rapidly spread throughout the world leading to high mortality rates. Despite the knowledge of previous diseases caused by viruses of the same family, such as MERS and SARS-CoV, management and treatment of patients with COVID-19 is a challenge. One of the best strategies around the world to help combat the COVID-19 has been directed to drug repositioning; however, these drugs are not specific to this new virus. Additionally, the pathophysiology of COVID-19 is highly heterogeneous, and the way of SARS-CoV-2 modulates the different systems in the host remains unidentified, despite recent discoveries. This complex and multifactorial response requires a comprehensive therapeutic approach, enabling the integration and refinement of therapeutic responses of a given single compound that has several action potentials. In this context, natural compounds, such as Curcumin, have shown beneficial effects on the progression of inflammatory diseases due to its numerous action mechanisms: antiviral, anti-inflammatory, anticoagulant, antiplatelet, and cytoprotective. These and many other effects of curcumin make it a promising target in the adjuvant treatment of COVID-19. Hence, the purpose of this review is to specifically point out how curcumin could interfere at different times/points during the infection caused by SARS-CoV-2, providing a substantial contribution of curcumin as a new adjuvant therapy for the treatment of COVID-19.
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spelling pubmed-81385672021-05-22 Curcumin as a Potential Treatment for COVID-19 Rattis, Bruna A. C. Ramos, Simone G. Celes, Mara R. N. Front Pharmacol Pharmacology Coronavirus disease 2019 (COVID-19) is an infectious disease that rapidly spread throughout the world leading to high mortality rates. Despite the knowledge of previous diseases caused by viruses of the same family, such as MERS and SARS-CoV, management and treatment of patients with COVID-19 is a challenge. One of the best strategies around the world to help combat the COVID-19 has been directed to drug repositioning; however, these drugs are not specific to this new virus. Additionally, the pathophysiology of COVID-19 is highly heterogeneous, and the way of SARS-CoV-2 modulates the different systems in the host remains unidentified, despite recent discoveries. This complex and multifactorial response requires a comprehensive therapeutic approach, enabling the integration and refinement of therapeutic responses of a given single compound that has several action potentials. In this context, natural compounds, such as Curcumin, have shown beneficial effects on the progression of inflammatory diseases due to its numerous action mechanisms: antiviral, anti-inflammatory, anticoagulant, antiplatelet, and cytoprotective. These and many other effects of curcumin make it a promising target in the adjuvant treatment of COVID-19. Hence, the purpose of this review is to specifically point out how curcumin could interfere at different times/points during the infection caused by SARS-CoV-2, providing a substantial contribution of curcumin as a new adjuvant therapy for the treatment of COVID-19. Frontiers Media S.A. 2021-05-07 /pmc/articles/PMC8138567/ /pubmed/34025433 http://dx.doi.org/10.3389/fphar.2021.675287 Text en Copyright © 2021 Rattis, Ramos and Celes. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Rattis, Bruna A. C.
Ramos, Simone G.
Celes, Mara R. N.
Curcumin as a Potential Treatment for COVID-19
title Curcumin as a Potential Treatment for COVID-19
title_full Curcumin as a Potential Treatment for COVID-19
title_fullStr Curcumin as a Potential Treatment for COVID-19
title_full_unstemmed Curcumin as a Potential Treatment for COVID-19
title_short Curcumin as a Potential Treatment for COVID-19
title_sort curcumin as a potential treatment for covid-19
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138567/
https://www.ncbi.nlm.nih.gov/pubmed/34025433
http://dx.doi.org/10.3389/fphar.2021.675287
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