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Current Status of Newborn Screening in Southeastern Europe

Significant part of Southeastern Europe (with a population of 76 million) has newborn screening (NBS) programs non-harmonized with developed European countries. Initial survey was conducted in 2013/2014 among 11 countries from the region (Albania, Bulgaria, Bosnia and Herzegovina (BIH), Croatia, Kos...

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Autores principales: Koracin, Vanesa, Mlinaric, Matej, Baric, Ivo, Brincat, Ian, Djordjevic, Maja, Drole Torkar, Ana, Fumic, Ksenija, Kocova, Mirjana, Milenkovic, Tatjana, Moldovanu, Florentina, Mulliqi Kotori, Vjosa, Nanu, Michaela Iuliana, Remec, Ziga Iztok, Repic Lampret, Barbka, Platis, Dimitrios, Savov, Alexey, Samardzic, Mira, Suzic, Biljana, Szatmari, Ildiko, Toromanovic, Alma, Zerjav Tansek, Mojca, Battelino, Tadej, Groselj, Urh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138576/
https://www.ncbi.nlm.nih.gov/pubmed/34026686
http://dx.doi.org/10.3389/fped.2021.648939
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author Koracin, Vanesa
Mlinaric, Matej
Baric, Ivo
Brincat, Ian
Djordjevic, Maja
Drole Torkar, Ana
Fumic, Ksenija
Kocova, Mirjana
Milenkovic, Tatjana
Moldovanu, Florentina
Mulliqi Kotori, Vjosa
Nanu, Michaela Iuliana
Remec, Ziga Iztok
Repic Lampret, Barbka
Platis, Dimitrios
Savov, Alexey
Samardzic, Mira
Suzic, Biljana
Szatmari, Ildiko
Toromanovic, Alma
Zerjav Tansek, Mojca
Battelino, Tadej
Groselj, Urh
author_facet Koracin, Vanesa
Mlinaric, Matej
Baric, Ivo
Brincat, Ian
Djordjevic, Maja
Drole Torkar, Ana
Fumic, Ksenija
Kocova, Mirjana
Milenkovic, Tatjana
Moldovanu, Florentina
Mulliqi Kotori, Vjosa
Nanu, Michaela Iuliana
Remec, Ziga Iztok
Repic Lampret, Barbka
Platis, Dimitrios
Savov, Alexey
Samardzic, Mira
Suzic, Biljana
Szatmari, Ildiko
Toromanovic, Alma
Zerjav Tansek, Mojca
Battelino, Tadej
Groselj, Urh
author_sort Koracin, Vanesa
collection PubMed
description Significant part of Southeastern Europe (with a population of 76 million) has newborn screening (NBS) programs non-harmonized with developed European countries. Initial survey was conducted in 2013/2014 among 11 countries from the region (Albania, Bulgaria, Bosnia and Herzegovina (BIH), Croatia, Kosovo, Macedonia, Moldova, Montenegro, Romania, Serbia, and Slovenia) to assess the main characteristics of their NBS programs and their future plans. Their cumulative population at that time was ~52,5 million. At that time, none of the countries had an expanded NBS program, while phenylketonuria screening was not introduced in four and congenital hypothyroidism in three of 11 countries. We repeated the survey in 2020 inviting the same 11 countries, adding Cyprus, Greece, Hungary, and Malta (due to their geographical position in the wider region). The aims were to assess the current state, to evaluate the change in the period, and to identify the main obstacles impacting the implementation of expanded NBS and/or reaching a wider population. Responses were collected from 12 countries (BIH—Federation of BIH, BIH—Republic of Srpska, Bulgaria, Croatia, Greece, Hungary, Kosovo, North Macedonia, Malta, Montenegro, Romania, Serbia, Slovenia) with a population of 68.5 million. The results of the survey showed that the regional situation regarding NBS only modestly improved in this period. All of the surveyed countries except Kosovo screened for at least congenital hypothyroidism, while phenylketonuria was not screened in four of 12 countries. Croatia and Slovenia implemented an expanded NBS program using tandem mass spectrometry from the time of last survey. In conclusion, the current status of NBS programs in Southeastern Europe is very variable and is still underdeveloped (or even non-existent) in some of the countries. We suggest establishing an international task-force to assist with implementation and harmonization of basic NBS services where needed.
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spelling pubmed-81385762021-05-22 Current Status of Newborn Screening in Southeastern Europe Koracin, Vanesa Mlinaric, Matej Baric, Ivo Brincat, Ian Djordjevic, Maja Drole Torkar, Ana Fumic, Ksenija Kocova, Mirjana Milenkovic, Tatjana Moldovanu, Florentina Mulliqi Kotori, Vjosa Nanu, Michaela Iuliana Remec, Ziga Iztok Repic Lampret, Barbka Platis, Dimitrios Savov, Alexey Samardzic, Mira Suzic, Biljana Szatmari, Ildiko Toromanovic, Alma Zerjav Tansek, Mojca Battelino, Tadej Groselj, Urh Front Pediatr Pediatrics Significant part of Southeastern Europe (with a population of 76 million) has newborn screening (NBS) programs non-harmonized with developed European countries. Initial survey was conducted in 2013/2014 among 11 countries from the region (Albania, Bulgaria, Bosnia and Herzegovina (BIH), Croatia, Kosovo, Macedonia, Moldova, Montenegro, Romania, Serbia, and Slovenia) to assess the main characteristics of their NBS programs and their future plans. Their cumulative population at that time was ~52,5 million. At that time, none of the countries had an expanded NBS program, while phenylketonuria screening was not introduced in four and congenital hypothyroidism in three of 11 countries. We repeated the survey in 2020 inviting the same 11 countries, adding Cyprus, Greece, Hungary, and Malta (due to their geographical position in the wider region). The aims were to assess the current state, to evaluate the change in the period, and to identify the main obstacles impacting the implementation of expanded NBS and/or reaching a wider population. Responses were collected from 12 countries (BIH—Federation of BIH, BIH—Republic of Srpska, Bulgaria, Croatia, Greece, Hungary, Kosovo, North Macedonia, Malta, Montenegro, Romania, Serbia, Slovenia) with a population of 68.5 million. The results of the survey showed that the regional situation regarding NBS only modestly improved in this period. All of the surveyed countries except Kosovo screened for at least congenital hypothyroidism, while phenylketonuria was not screened in four of 12 countries. Croatia and Slovenia implemented an expanded NBS program using tandem mass spectrometry from the time of last survey. In conclusion, the current status of NBS programs in Southeastern Europe is very variable and is still underdeveloped (or even non-existent) in some of the countries. We suggest establishing an international task-force to assist with implementation and harmonization of basic NBS services where needed. Frontiers Media S.A. 2021-05-07 /pmc/articles/PMC8138576/ /pubmed/34026686 http://dx.doi.org/10.3389/fped.2021.648939 Text en Copyright © 2021 Koracin, Mlinaric, Baric, Brincat, Djordjevic, Drole Torkar, Fumic, Kocova, Milenkovic, Moldovanu, Mulliqi Kotori, Nanu, Remec, Repic Lampret, Platis, Savov, Samardzic, Suzic, Szatmari, Toromanovic, Zerjav Tansek, Battelino and Groselj. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Koracin, Vanesa
Mlinaric, Matej
Baric, Ivo
Brincat, Ian
Djordjevic, Maja
Drole Torkar, Ana
Fumic, Ksenija
Kocova, Mirjana
Milenkovic, Tatjana
Moldovanu, Florentina
Mulliqi Kotori, Vjosa
Nanu, Michaela Iuliana
Remec, Ziga Iztok
Repic Lampret, Barbka
Platis, Dimitrios
Savov, Alexey
Samardzic, Mira
Suzic, Biljana
Szatmari, Ildiko
Toromanovic, Alma
Zerjav Tansek, Mojca
Battelino, Tadej
Groselj, Urh
Current Status of Newborn Screening in Southeastern Europe
title Current Status of Newborn Screening in Southeastern Europe
title_full Current Status of Newborn Screening in Southeastern Europe
title_fullStr Current Status of Newborn Screening in Southeastern Europe
title_full_unstemmed Current Status of Newborn Screening in Southeastern Europe
title_short Current Status of Newborn Screening in Southeastern Europe
title_sort current status of newborn screening in southeastern europe
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138576/
https://www.ncbi.nlm.nih.gov/pubmed/34026686
http://dx.doi.org/10.3389/fped.2021.648939
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