Effects of Antiarrhythmic Drugs on hERG Gating in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1

Aims: The short QT syndrome type 1 (SQT1) is linked to hERG channel mutations (e.g., N588K). Drug effects on hERG channel gating kinetics in SQT1-cells have not been investigated. Methods: This study used hiPSC-CMs of a healthy donor and a SQT1-patient carrying the N588K mutation and patch clamp to...

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Detalles Bibliográficos
Autores principales: Huang, Mengying, Liao, Zhenxing, Li, Xin, Yang, Zhen, Fan, Xuehui, Li, Yingrui, Zhao, Zhihan, Lang, Siegfried, Cyganek, Lukas, Zhou, Xiaobo, Akin, Ibrahim, Borggrefe, Martin, El-Battrawy, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138577/
https://www.ncbi.nlm.nih.gov/pubmed/34025432
http://dx.doi.org/10.3389/fphar.2021.675003

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