Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment

Tristetraprolin (TTP), a well-known RNA-binding protein, primarily affects the expression of inflammation-related proteins by binding to the targeted AU-rich element in the 3’ untranslated region after transcription and subsequently mediates messenger RNA decay. Recent studies have focused on the ro...

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Autores principales: Zhang, Diwen, Zhou, Zhigang, Yang, Ruixia, Zhang, Sujun, Zhang, Bin, Tan, Yanxuan, Chen, Lingyao, Li, Tao, Tu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138596/
https://www.ncbi.nlm.nih.gov/pubmed/34026612
http://dx.doi.org/10.3389/fonc.2021.632189
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author Zhang, Diwen
Zhou, Zhigang
Yang, Ruixia
Zhang, Sujun
Zhang, Bin
Tan, Yanxuan
Chen, Lingyao
Li, Tao
Tu, Jian
author_facet Zhang, Diwen
Zhou, Zhigang
Yang, Ruixia
Zhang, Sujun
Zhang, Bin
Tan, Yanxuan
Chen, Lingyao
Li, Tao
Tu, Jian
author_sort Zhang, Diwen
collection PubMed
description Tristetraprolin (TTP), a well-known RNA-binding protein, primarily affects the expression of inflammation-related proteins by binding to the targeted AU-rich element in the 3’ untranslated region after transcription and subsequently mediates messenger RNA decay. Recent studies have focused on the role of TTP in tumors and their related microenvironments, most of which have referred to TTP as a potential tumor suppressor involved in regulating cell proliferation, apoptosis, and metastasis of various cancers, as well as tumor immunity, inflammation, and metabolism of the microenvironment. Elevated TTP expression levels could aid the diagnosis and treatment of different cancers, improving the prognosis of patients. The aim of this review is to describe the role of TTP as a potential safeguard against carcinoma.
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spelling pubmed-81385962021-05-22 Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment Zhang, Diwen Zhou, Zhigang Yang, Ruixia Zhang, Sujun Zhang, Bin Tan, Yanxuan Chen, Lingyao Li, Tao Tu, Jian Front Oncol Oncology Tristetraprolin (TTP), a well-known RNA-binding protein, primarily affects the expression of inflammation-related proteins by binding to the targeted AU-rich element in the 3’ untranslated region after transcription and subsequently mediates messenger RNA decay. Recent studies have focused on the role of TTP in tumors and their related microenvironments, most of which have referred to TTP as a potential tumor suppressor involved in regulating cell proliferation, apoptosis, and metastasis of various cancers, as well as tumor immunity, inflammation, and metabolism of the microenvironment. Elevated TTP expression levels could aid the diagnosis and treatment of different cancers, improving the prognosis of patients. The aim of this review is to describe the role of TTP as a potential safeguard against carcinoma. Frontiers Media S.A. 2021-05-07 /pmc/articles/PMC8138596/ /pubmed/34026612 http://dx.doi.org/10.3389/fonc.2021.632189 Text en Copyright © 2021 Zhang, Zhou, Yang, Zhang, Zhang, Tan, Chen, Li and Tu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Diwen
Zhou, Zhigang
Yang, Ruixia
Zhang, Sujun
Zhang, Bin
Tan, Yanxuan
Chen, Lingyao
Li, Tao
Tu, Jian
Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment
title Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment
title_full Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment
title_fullStr Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment
title_full_unstemmed Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment
title_short Tristetraprolin, a Potential Safeguard Against Carcinoma: Role in the Tumor Microenvironment
title_sort tristetraprolin, a potential safeguard against carcinoma: role in the tumor microenvironment
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138596/
https://www.ncbi.nlm.nih.gov/pubmed/34026612
http://dx.doi.org/10.3389/fonc.2021.632189
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