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Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration

Intrauterine adhesions (IUAs) refer to the repair disorder after endometrial injury and may lead to uterine infertility, recurrent miscarriage, abnormal menstrual bleeding, and other obstetric complications. It is a pressing public health issue among women of childbearing age. Presently, there are l...

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Detalles Bibliográficos
Autores principales: Li, X., Lv, H.-F., Zhao, R., Ying, M.-f., Samuriwo, A.T., Zhao, Y.-Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138682/
https://www.ncbi.nlm.nih.gov/pubmed/34036261
http://dx.doi.org/10.1016/j.mtbio.2021.100101
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author Li, X.
Lv, H.-F.
Zhao, R.
Ying, M.-f.
Samuriwo, A.T.
Zhao, Y.-Z.
author_facet Li, X.
Lv, H.-F.
Zhao, R.
Ying, M.-f.
Samuriwo, A.T.
Zhao, Y.-Z.
author_sort Li, X.
collection PubMed
description Intrauterine adhesions (IUAs) refer to the repair disorder after endometrial injury and may lead to uterine infertility, recurrent miscarriage, abnormal menstrual bleeding, and other obstetric complications. It is a pressing public health issue among women of childbearing age. Presently, there are limited clinical treatments for IUA, and there is no sufficient evidence that these treatment modalities can effectively promote regeneration after severe endometrial injury or improve pregnancy outcome. The inhibitory pathological micro-environment is the main factor hindering the repair of endometrial damaged tissues. To address this, tissue engineering and regenerative medicine have been achieving promising developments. Particularly, biomaterials have been used to load stem cells or therapeutic factors or construct an in situ delivery system as a treatment strategy for endometrial injury repair. This article comprehensively discusses the characteristics of various bio-scaffold materials and their application as stem cell or therapeutic factor delivery systems constructed for uterine tissue regeneration.
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spelling pubmed-81386822021-05-24 Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration Li, X. Lv, H.-F. Zhao, R. Ying, M.-f. Samuriwo, A.T. Zhao, Y.-Z. Mater Today Bio Review Article Intrauterine adhesions (IUAs) refer to the repair disorder after endometrial injury and may lead to uterine infertility, recurrent miscarriage, abnormal menstrual bleeding, and other obstetric complications. It is a pressing public health issue among women of childbearing age. Presently, there are limited clinical treatments for IUA, and there is no sufficient evidence that these treatment modalities can effectively promote regeneration after severe endometrial injury or improve pregnancy outcome. The inhibitory pathological micro-environment is the main factor hindering the repair of endometrial damaged tissues. To address this, tissue engineering and regenerative medicine have been achieving promising developments. Particularly, biomaterials have been used to load stem cells or therapeutic factors or construct an in situ delivery system as a treatment strategy for endometrial injury repair. This article comprehensively discusses the characteristics of various bio-scaffold materials and their application as stem cell or therapeutic factor delivery systems constructed for uterine tissue regeneration. Elsevier 2021-02-25 /pmc/articles/PMC8138682/ /pubmed/34036261 http://dx.doi.org/10.1016/j.mtbio.2021.100101 Text en © 2021 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Li, X.
Lv, H.-F.
Zhao, R.
Ying, M.-f.
Samuriwo, A.T.
Zhao, Y.-Z.
Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration
title Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration
title_full Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration
title_fullStr Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration
title_full_unstemmed Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration
title_short Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration
title_sort recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138682/
https://www.ncbi.nlm.nih.gov/pubmed/34036261
http://dx.doi.org/10.1016/j.mtbio.2021.100101
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