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CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells

Pregnenolone (P5) promotes prostate cancer cell growth, and de novo synthesis of intratumoural P5 is a potential cause of development of castration resistance. Immune cells can also synthesize P5 de novo. Despite its biological importance, little is known about P5's mode of actions, which appea...

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Detalles Bibliográficos
Autores principales:	Roy, Sougata, Sipthorp, James, Mahata, Bidesh, Pramanik, Jhuma, Hennrich, Marco L., Gavin, Anne-Claude, Ley, Steven V., Teichmann, Sarah A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138728/ https://www.ncbi.nlm.nih.gov/pubmed/34036248 http://dx.doi.org/10.1016/j.isci.2021.102485

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