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Dissociation of the G protein βγ from the Gq–PLCβ complex partially attenuates PIP2 hydrolysis

Phospholipase C β (PLCβ), which is activated by the Gq family of heterotrimeric G proteins, hydrolyzes the inner membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), generating diacylglycerol and inositol 1,4,5-triphosphate (IP3). Because Gq and PLCβ regulate many crucial cellular processes...

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Detalles Bibliográficos
Autores principales:	Kankanamge, Dinesh, Ubeysinghe, Sithurandi, Tennakoon, Mithila, Pantula, Priyanka Devi, Mitra, Kishalay, Giri, Lopamudra, Karunarathne, Ajith
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138763/ https://www.ncbi.nlm.nih.gov/pubmed/33901492 http://dx.doi.org/10.1016/j.jbc.2021.100702

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