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Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity

Speckle-type POZ protein (SPOP) is a ubiquitin ligase adaptor that binds substrate proteins and facilitates their proteasomal degradation. Most SPOP substrates present multiple SPOP-binding (SB) motifs and undergo liquid–liquid phase separation with SPOP. Pancreatic and duodenal homeobox 1 (Pdx1), a...

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Detalles Bibliográficos
Autores principales:	Usher, Emery T., Sabri, Nafiseh, Rohac, Roman, Boal, Amie K., Mittag, Tanja, Showalter, Scott A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138767/ https://www.ncbi.nlm.nih.gov/pubmed/33894201 http://dx.doi.org/10.1016/j.jbc.2021.100693

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