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An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel

BACKGROUND: The amino acid sequence of proteins generally carries all the necessary information for acquisition of native conformations, but the vectorial nature of translation can additionally determine the folding outcome. Such consideration is particularly relevant in human diseases associated to...

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Detalles Bibliográficos
Autores principales:	Urrutia, Janire, Aguado, Alejandra, Gomis-Perez, Carolina, Muguruza-Montero, Arantza, Ballesteros, Oscar R., Zhang, Jiaren, Nuñez, Eider, Malo, Covadonga, Chung, Hee Jung, Leonardo, Aritz, Bergara, Aitor, Villarroel, Alvaro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138981/ https://www.ncbi.nlm.nih.gov/pubmed/34020651 http://dx.doi.org/10.1186/s12915-021-01040-1

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