Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain

BACKGROUND: Calcitonin gene-related peptide (CGRP) as a mediator of microglial activation at the transcriptional level may facilitate nociceptive signaling. Trimethylation of H3 lysine 27 (H3K27me3) by enhancer of zeste homolog 2 (EZH2) is an epigenetic mark that regulates inflammatory-related gene...

Descripción completa

Detalles Bibliográficos
Autores principales: An, Qi, Sun, Chenyan, Li, Ruidi, Chen, Shuhui, Gu, Xinpei, An, Shuhong, Wang, Zhaojin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139106/
https://www.ncbi.nlm.nih.gov/pubmed/34020664
http://dx.doi.org/10.1186/s12974-021-02168-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139106/
https://www.ncbi.nlm.nih.gov/pubmed/34020664
http://dx.doi.org/10.1186/s12974-021-02168-1

Ejemplares similares