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Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain

BACKGROUND: Calcitonin gene-related peptide (CGRP) as a mediator of microglial activation at the transcriptional level may facilitate nociceptive signaling. Trimethylation of H3 lysine 27 (H3K27me3) by enhancer of zeste homolog 2 (EZH2) is an epigenetic mark that regulates inflammatory-related gene...

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Detalles Bibliográficos
Autores principales:	An, Qi, Sun, Chenyan, Li, Ruidi, Chen, Shuhui, Gu, Xinpei, An, Shuhong, Wang, Zhaojin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139106/ https://www.ncbi.nlm.nih.gov/pubmed/34020664 http://dx.doi.org/10.1186/s12974-021-02168-1

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