Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence

Misfolded forms of superoxide dismutase 1 (SOD1) with mutations associated with familial amyotrophic lateral sclerosis (fALS) exhibit prion characteristics, including the ability to act as seeds to accelerate motor neuron disease in mouse models. A key feature of infectious prion seeding is that the...

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Detalles Bibliográficos
Autores principales: Ayers, Jacob I., Xu, Guilian, Dillon, Kristy, Lu, Qing, Chen, Zhijuan, Beckman, John, Moreno-Romero, Alma K., Zamora, Diana L., Galaleldeen, Ahmad, Borchelt, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139116/
https://www.ncbi.nlm.nih.gov/pubmed/34016165
http://dx.doi.org/10.1186/s40478-021-01191-w

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