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Association of arterial stiffness with incident atrial fibrillation: a cohort study

BACKGROUND: Stiff arteries increase left ventricular (LV) end-systolic workload, leading over time to left atrial and ventricular remodeling, and providing the substrate for atrial fibrillation (AF) development. We investigated if carotid femoral pulse wave velocity (cfPWV), a measure of central art...

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Autores principales: Almuwaqqat, Zakaria, Claxton, J.Neka S., Norby, Faye L., Lutsey, Pamela L., Wei, Jingkai, Soliman, Elsayed Z., Chen, Lin Y., Matsushita, Kunihiro, Heiss, Gerardo, Alonso, Alvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139144/
https://www.ncbi.nlm.nih.gov/pubmed/34016038
http://dx.doi.org/10.1186/s12872-021-02057-8
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author Almuwaqqat, Zakaria
Claxton, J.Neka S.
Norby, Faye L.
Lutsey, Pamela L.
Wei, Jingkai
Soliman, Elsayed Z.
Chen, Lin Y.
Matsushita, Kunihiro
Heiss, Gerardo
Alonso, Alvaro
author_facet Almuwaqqat, Zakaria
Claxton, J.Neka S.
Norby, Faye L.
Lutsey, Pamela L.
Wei, Jingkai
Soliman, Elsayed Z.
Chen, Lin Y.
Matsushita, Kunihiro
Heiss, Gerardo
Alonso, Alvaro
author_sort Almuwaqqat, Zakaria
collection PubMed
description BACKGROUND: Stiff arteries increase left ventricular (LV) end-systolic workload, leading over time to left atrial and ventricular remodeling, and providing the substrate for atrial fibrillation (AF) development. We investigated if carotid femoral pulse wave velocity (cfPWV), a measure of central arterial stiffness, is associated with incident AF. METHODS: In 20112013, cfPWV was measured in 3882 participants of the Atherosclerosis Risk in Communities Cohort Study (ARIC) without prevalent AF. Participants were followed through 2017 for the incidence of AF. Individuals were categorized in cfPWV quartiles based on visit measurements. Multivariable Cox regression models were used to evaluate the association of cfPWV with incident AF. RESULTS: Mean age was 75years (SD 5), 60% were female and 20% were African American. Over a median follow-up of 5.5years we identified 331 incident cases of AF. cfPWV demonstrated U-shaped associations with AF risk. In models adjusted for age, race, center, sex, education levels, and hemodynamic and clinical factors, hazard ratios (HR) of AF for participants in the first, third and fourth quartiles were 1.49 (95% CI 1.06, 2.10), 1.59 (1.14, 2.10), and 1.56(1.10, 2.19), respectively, compared to those in the second quartile. CONCLUSION: Among community-dwelling older adults, low and high central arterial stiffness is associated with AF risk. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-021-02057-8.
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spelling pubmed-81391442021-05-25 Association of arterial stiffness with incident atrial fibrillation: a cohort study Almuwaqqat, Zakaria Claxton, J.Neka S. Norby, Faye L. Lutsey, Pamela L. Wei, Jingkai Soliman, Elsayed Z. Chen, Lin Y. Matsushita, Kunihiro Heiss, Gerardo Alonso, Alvaro BMC Cardiovasc Disord Research BACKGROUND: Stiff arteries increase left ventricular (LV) end-systolic workload, leading over time to left atrial and ventricular remodeling, and providing the substrate for atrial fibrillation (AF) development. We investigated if carotid femoral pulse wave velocity (cfPWV), a measure of central arterial stiffness, is associated with incident AF. METHODS: In 20112013, cfPWV was measured in 3882 participants of the Atherosclerosis Risk in Communities Cohort Study (ARIC) without prevalent AF. Participants were followed through 2017 for the incidence of AF. Individuals were categorized in cfPWV quartiles based on visit measurements. Multivariable Cox regression models were used to evaluate the association of cfPWV with incident AF. RESULTS: Mean age was 75years (SD 5), 60% were female and 20% were African American. Over a median follow-up of 5.5years we identified 331 incident cases of AF. cfPWV demonstrated U-shaped associations with AF risk. In models adjusted for age, race, center, sex, education levels, and hemodynamic and clinical factors, hazard ratios (HR) of AF for participants in the first, third and fourth quartiles were 1.49 (95% CI 1.06, 2.10), 1.59 (1.14, 2.10), and 1.56(1.10, 2.19), respectively, compared to those in the second quartile. CONCLUSION: Among community-dwelling older adults, low and high central arterial stiffness is associated with AF risk. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12872-021-02057-8. BioMed Central 2021-05-20 /pmc/articles/PMC8139144/ /pubmed/34016038 http://dx.doi.org/10.1186/s12872-021-02057-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Almuwaqqat, Zakaria
Claxton, J.Neka S.
Norby, Faye L.
Lutsey, Pamela L.
Wei, Jingkai
Soliman, Elsayed Z.
Chen, Lin Y.
Matsushita, Kunihiro
Heiss, Gerardo
Alonso, Alvaro
Association of arterial stiffness with incident atrial fibrillation: a cohort study
title Association of arterial stiffness with incident atrial fibrillation: a cohort study
title_full Association of arterial stiffness with incident atrial fibrillation: a cohort study
title_fullStr Association of arterial stiffness with incident atrial fibrillation: a cohort study
title_full_unstemmed Association of arterial stiffness with incident atrial fibrillation: a cohort study
title_short Association of arterial stiffness with incident atrial fibrillation: a cohort study
title_sort association of arterial stiffness with incident atrial fibrillation: a cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139144/
https://www.ncbi.nlm.nih.gov/pubmed/34016038
http://dx.doi.org/10.1186/s12872-021-02057-8
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