CpG oligodeoxynucleotides attenuate RORt-mediated Th17 response by restoring histone deacetylase-2 in cigarette smoke-exposure asthma

BACKGROUND: Cigarette smoke (CS) exposure increases corticosteroid insensitive asthma related to increased Th17 phenotype, and new treatment strategies are needed for CS-associated asthma. Histone deacetylase 2 (HDAC2), found in the airway epithelium, is critical for ameliorating glucocorticoids ins...

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Detalles Bibliográficos
Autores principales: Li, Hongtao, Ye, Qimei, Lin, Yusen, Yang, Xuena, Zou, Xiaoling, Yang, Hailing, Wu, Wenbin, Meng, Ping, Zhang, Tiantuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139164/
https://www.ncbi.nlm.nih.gov/pubmed/34016172
http://dx.doi.org/10.1186/s13578-021-00607-3

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