Age-Related Cognitive and Motor Decline in a Mouse Model of CDKL5 Deficiency Disorder is Associated with Increased Neuronal Senescence and Death

CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene. Children affected by CDD display a clinical phenotype characterized by early-onset epilepsy, intellectual disability, motor impairment, and autistic-like features. Although the clin...

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Detalles Bibliográficos
Autores principales: Gennaccaro, Laura, Fuchs, Claudia, Loi, Manuela, Pizzo, Riccardo, Alvente, Sara, Berteotti, Chiara, Lupori, Leonardo, Sagona, Giulia, Galvani, Giuseppe, Gurgone, Antonia, Raspanti, Alessandra, Medici, Giorgio, Tassinari, Marianna, Trazzi, Stefania, Ren, Elisa, Rimondini, Roberto, Pizzorusso, Tommaso, Zoccoli, Giovanna, Giustetto, Maurizio, Ciani, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2021
Materias:
Orginal Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139207/
https://www.ncbi.nlm.nih.gov/pubmed/34094641
http://dx.doi.org/10.14336/AD.2020.0827

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