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Obesity and Sarcopenia in Survivors of Childhood Acute Lymphoblastic Leukemia

OBJECTIVE: To describe the prevalence of obesity and sarcopenia among survivors of childhood acute lymphoblastic leukemia (ALL) using DEXA scan, and study associated risk factors. METHODS: This case control study was conducted between July, 2013 and June, 2014 at a tertiary care cancer centre in Ind...

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Autores principales: Malhotra, Payal, Kapoor, Gauri, Jain, Sandeep, Jain, Silky, Sharma, Anurag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139219/
https://www.ncbi.nlm.nih.gov/pubmed/33408276
http://dx.doi.org/10.1007/s13312-021-2213-7
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author Malhotra, Payal
Kapoor, Gauri
Jain, Sandeep
Jain, Silky
Sharma, Anurag
author_facet Malhotra, Payal
Kapoor, Gauri
Jain, Sandeep
Jain, Silky
Sharma, Anurag
author_sort Malhotra, Payal
collection PubMed
description OBJECTIVE: To describe the prevalence of obesity and sarcopenia among survivors of childhood acute lymphoblastic leukemia (ALL) using DEXA scan, and study associated risk factors. METHODS: This case control study was conducted between July, 2013 and June, 2014 at a tertiary care cancer centre in India. Study participants included 65 survivors of childhood ALL who were <18 years of age at diagnosis, treated between years 1996 and 2008, and were at least two years since completion of therapy. The controls included 50 matched siblings. Dual energy X-ray absorptiometry (DEXA) was used to study the body composition (body fat percentage, BF% and lean body mass, LBM) of the participants and controls. McCarthys body fat reference data were applied and logistic regression analysis was used to study various risk factors. RESULTS: At a median (range) follow-up of 5 (7.217.2) years, BF% (DEXA) identified a significantly higher prevalence of obesity of 21.5% (14/65) and sarcopenic obesity (14%) among survivors as compared to the controls (0/50, P<0.001), while the prevalence of sarcopenia as detected by LBM was similar at 60% (39/65) and 56% (28/50), respectively. On multivariate analysis, age at evaluation, high-risk disease and cranial irradiation were independently associated with high likelihood of obesity, while none of the factors predicted sarcopenia. CONCLUSION: High prevalence of obesity and sarcopenic obesity were observed among survivors of childhood ALL.
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spelling pubmed-81392192021-05-24 Obesity and Sarcopenia in Survivors of Childhood Acute Lymphoblastic Leukemia Malhotra, Payal Kapoor, Gauri Jain, Sandeep Jain, Silky Sharma, Anurag Indian Pediatr Research Paper OBJECTIVE: To describe the prevalence of obesity and sarcopenia among survivors of childhood acute lymphoblastic leukemia (ALL) using DEXA scan, and study associated risk factors. METHODS: This case control study was conducted between July, 2013 and June, 2014 at a tertiary care cancer centre in India. Study participants included 65 survivors of childhood ALL who were <18 years of age at diagnosis, treated between years 1996 and 2008, and were at least two years since completion of therapy. The controls included 50 matched siblings. Dual energy X-ray absorptiometry (DEXA) was used to study the body composition (body fat percentage, BF% and lean body mass, LBM) of the participants and controls. McCarthys body fat reference data were applied and logistic regression analysis was used to study various risk factors. RESULTS: At a median (range) follow-up of 5 (7.217.2) years, BF% (DEXA) identified a significantly higher prevalence of obesity of 21.5% (14/65) and sarcopenic obesity (14%) among survivors as compared to the controls (0/50, P<0.001), while the prevalence of sarcopenia as detected by LBM was similar at 60% (39/65) and 56% (28/50), respectively. On multivariate analysis, age at evaluation, high-risk disease and cranial irradiation were independently associated with high likelihood of obesity, while none of the factors predicted sarcopenia. CONCLUSION: High prevalence of obesity and sarcopenic obesity were observed among survivors of childhood ALL. Springer India 2021-01-02 2021 /pmc/articles/PMC8139219/ /pubmed/33408276 http://dx.doi.org/10.1007/s13312-021-2213-7 Text en © Indian Academy of Pediatrics 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Paper
Malhotra, Payal
Kapoor, Gauri
Jain, Sandeep
Jain, Silky
Sharma, Anurag
Obesity and Sarcopenia in Survivors of Childhood Acute Lymphoblastic Leukemia
title Obesity and Sarcopenia in Survivors of Childhood Acute Lymphoblastic Leukemia
title_full Obesity and Sarcopenia in Survivors of Childhood Acute Lymphoblastic Leukemia
title_fullStr Obesity and Sarcopenia in Survivors of Childhood Acute Lymphoblastic Leukemia
title_full_unstemmed Obesity and Sarcopenia in Survivors of Childhood Acute Lymphoblastic Leukemia
title_short Obesity and Sarcopenia in Survivors of Childhood Acute Lymphoblastic Leukemia
title_sort obesity and sarcopenia in survivors of childhood acute lymphoblastic leukemia
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139219/
https://www.ncbi.nlm.nih.gov/pubmed/33408276
http://dx.doi.org/10.1007/s13312-021-2213-7
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