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Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases
Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individuals quality of life. Although bone has the innate ability to remode...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139407/ https://www.ncbi.nlm.nih.gov/pubmed/34026739 http://dx.doi.org/10.3389/fbioe.2021.616555 |
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author | Khan, Suliman Siddique, Rabeea Huanfei, Ding Shereen, Muhammad Adnan Nabi, Ghulam Bai, Qian Manan, Sehrish Xue, Mengzhou Ullah, Muhammad Wajid Bowen, Hu |
author_facet | Khan, Suliman Siddique, Rabeea Huanfei, Ding Shereen, Muhammad Adnan Nabi, Ghulam Bai, Qian Manan, Sehrish Xue, Mengzhou Ullah, Muhammad Wajid Bowen, Hu |
author_sort | Khan, Suliman |
collection | PubMed |
description | Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individuals quality of life. Although bone has the innate ability to remodel and regenerate in case of small damage or a crack, a loss of a large volume of bone in case of a traumatic injury requires the restoration of bone function by adopting different biophysical approaches and chemotherapies as well as a surgical reconstruction. Compared to the biophysical and chemotherapeutic approaches, which may cause complications and bear side effects, the surgical reconstruction involves the implantation of external materials such as ceramics, metals, and different other materials as bone substitutes. Compared to the synthetic substitutes, the use of biomaterials could be an ideal choice for bone regeneration owing to their renewability, non-toxicity, and non-immunogenicity. Among the different types of biomaterials, nanocellulose-based materials are receiving tremendous attention in the medical field during recent years, which are used for scaffolding as well as regeneration. Nanocellulose not only serves as the matrix for the deposition of bioceramics, metallic nanoparticles, polymers, and different other materials to develop bone substitutes but also serves as the drug carrier for treating osteosarcomas. This review describes the natural sources and production of nanocellulose and discusses its important properties to justify its suitability in developing scaffolds for bone and cartilage regeneration and serve as the matrix for reinforcement of different materials and as a drug carrier for treating osteosarcomas. It discusses the potential health risks, immunogenicity, and biodegradation of nanocellulose in the human body. |
format | Online Article Text |
id | pubmed-8139407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81394072021-05-22 Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases Khan, Suliman Siddique, Rabeea Huanfei, Ding Shereen, Muhammad Adnan Nabi, Ghulam Bai, Qian Manan, Sehrish Xue, Mengzhou Ullah, Muhammad Wajid Bowen, Hu Front Bioeng Biotechnol Bioengineering and Biotechnology Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individuals quality of life. Although bone has the innate ability to remodel and regenerate in case of small damage or a crack, a loss of a large volume of bone in case of a traumatic injury requires the restoration of bone function by adopting different biophysical approaches and chemotherapies as well as a surgical reconstruction. Compared to the biophysical and chemotherapeutic approaches, which may cause complications and bear side effects, the surgical reconstruction involves the implantation of external materials such as ceramics, metals, and different other materials as bone substitutes. Compared to the synthetic substitutes, the use of biomaterials could be an ideal choice for bone regeneration owing to their renewability, non-toxicity, and non-immunogenicity. Among the different types of biomaterials, nanocellulose-based materials are receiving tremendous attention in the medical field during recent years, which are used for scaffolding as well as regeneration. Nanocellulose not only serves as the matrix for the deposition of bioceramics, metallic nanoparticles, polymers, and different other materials to develop bone substitutes but also serves as the drug carrier for treating osteosarcomas. This review describes the natural sources and production of nanocellulose and discusses its important properties to justify its suitability in developing scaffolds for bone and cartilage regeneration and serve as the matrix for reinforcement of different materials and as a drug carrier for treating osteosarcomas. It discusses the potential health risks, immunogenicity, and biodegradation of nanocellulose in the human body. Frontiers Media S.A. 2021-05-07 /pmc/articles/PMC8139407/ /pubmed/34026739 http://dx.doi.org/10.3389/fbioe.2021.616555 Text en Copyright 2021 Khan, Siddique, Huanfei, Shereen, Nabi, Bai, Manan, Xue, Ullah and Bowen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Khan, Suliman Siddique, Rabeea Huanfei, Ding Shereen, Muhammad Adnan Nabi, Ghulam Bai, Qian Manan, Sehrish Xue, Mengzhou Ullah, Muhammad Wajid Bowen, Hu Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases |
title | Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases |
title_full | Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases |
title_fullStr | Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases |
title_full_unstemmed | Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases |
title_short | Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases |
title_sort | perspective applications and associated challenges of using nanocellulose in treating bone-related diseases |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139407/ https://www.ncbi.nlm.nih.gov/pubmed/34026739 http://dx.doi.org/10.3389/fbioe.2021.616555 |
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