SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation

Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical manifestations affecting the lungs, liver, kidneys and gut. Angiotensin converting enzyme (ACE) 2, the best-characterized entry receptor for the disease-causing virus SARS-CoV-2, is highly expressed in the afore...

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Detalles Bibliográficos
Autores principales: Yan, Bingyu, Freiwald, Tilo, Chauss, Daniel, Wang, Luopin, West, Erin, Mirabelli, Carmen, Zhang, Charles J, Nichols, Eva-Maria, Malik, Nazish, Gregory, Richard, Bantscheff, Marcus, Ghidelli-Disse, Sonja, Kolev, Martin, Frum, Tristan, Spence, Jason R, Sexton, Jonathan Z., Alysandratos, Konstantinos D., Kotton, Darrell N., Pittaluga, Stefania, Bibby, Jack, Niyonzima, Nathalie, Olson, Matthew R, Kordasti, Shahram, Portilla, Didier, Wobus, Christiane E, Laurence, Arian, Lionakis, Michail S, Kemper, Claudia, Afzali, Behdad, Kazemian, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139422/
https://www.ncbi.nlm.nih.gov/pubmed/33827897
http://dx.doi.org/10.1126/sciimmunol.abg0833

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