SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8(+) T cell activation in COVID-19 patients

T cells are important for effective viral clearance, elimination of virus-infected cells and long-term disease protection. To examine the full-spectrum of CD8(+) T cell immunity in COVID-19, we experimentally evaluated 3141 major histocompatibility (MHC) class I-binding peptides covering the complet...

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Detalles Bibliográficos
Autores principales: Saini, Sunil Kumar, Hersby, Ditte Stampe, Tamhane, Tripti, Povlsen, Helle Rus, Amaya Hernandez, Susana Patricia, Nielsen, Morten, Gang, Anne Ortved, Hadrup, Sine Reker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139428/
https://www.ncbi.nlm.nih.gov/pubmed/33853928
http://dx.doi.org/10.1126/sciimmunol.abf7550

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