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Repeatability and agreement of biometric measurements using spectral domain anterior segment optical coherence tomography and Scheimpflug tomography in keratoconus

PURPOSE: To compare the repeatability and agreement in biometric measurements using Spectral Domain Anterior Segment OCT (AS-OCT, REVO-NX, Optopol) and Scheimpflug tomography (Pentacam-AXL, Oculus) in keratoconus. METHODS: Prospective case series at a university hospital tertiary center. Axial lengt...

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Autores principales: Li, Ye, Gokul, Akilesh, McGhee, Charles, Ziaei, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139453/
https://www.ncbi.nlm.nih.gov/pubmed/34019547
http://dx.doi.org/10.1371/journal.pone.0248659
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author Li, Ye
Gokul, Akilesh
McGhee, Charles
Ziaei, Mohammed
author_facet Li, Ye
Gokul, Akilesh
McGhee, Charles
Ziaei, Mohammed
author_sort Li, Ye
collection PubMed
description PURPOSE: To compare the repeatability and agreement in biometric measurements using Spectral Domain Anterior Segment OCT (AS-OCT, REVO-NX, Optopol) and Scheimpflug tomography (Pentacam-AXL, Oculus) in keratoconus. METHODS: Prospective case series at a university hospital tertiary center. Axial length (AL), anterior chamber depth (ACD), central corneal thickness (CCT), and thinnest corneal thickness (TCT) were measured using both devices in patients with keratoconus. Three groups were analyzed: eyes with no prior crosslinking or contact lens wear (Group A), eyes with prior crosslinking (Group B), and eyes with prior contact lens wear (Group C). Repeatability and agreement of measurements were analyzed. RESULTS: The study comprised of 214 eyes of 157 subjects. In Group A (n = 95 eyes), Group B (n = 86 eyes), and Group C (n = 33 eyes), intraclass correlation coefficient (ICC) was higher than 0.90 for all examined parameters, except for ACD readings in Group A with the REVO-NX (ICC = 0.83). Differences in ACD, TCT, and CCT were significantly different between the two devices for Groups A, B and C (p<0.05). AL measurements differed significantly in Groups A and B (p<0.05) but not in Group C (p = 0.18). Repeatability did not vary significantly between Groups A, B, or C in any parameter with both devices (p>0.05). There was poor agreement between the two devices across all parameters (p<0.05). CONCLUSIONS: Both devices demonstrated good repeatability but poor agreement across AL, ACD, CCT and TCT measurements. There was no significant difference in repeatability in virgin eyes compared to eyes with prior crosslinking or contact lens wear, however, the interchangeable use of the two devices is not recommended.
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spelling pubmed-81394532021-06-02 Repeatability and agreement of biometric measurements using spectral domain anterior segment optical coherence tomography and Scheimpflug tomography in keratoconus Li, Ye Gokul, Akilesh McGhee, Charles Ziaei, Mohammed PLoS One Research Article PURPOSE: To compare the repeatability and agreement in biometric measurements using Spectral Domain Anterior Segment OCT (AS-OCT, REVO-NX, Optopol) and Scheimpflug tomography (Pentacam-AXL, Oculus) in keratoconus. METHODS: Prospective case series at a university hospital tertiary center. Axial length (AL), anterior chamber depth (ACD), central corneal thickness (CCT), and thinnest corneal thickness (TCT) were measured using both devices in patients with keratoconus. Three groups were analyzed: eyes with no prior crosslinking or contact lens wear (Group A), eyes with prior crosslinking (Group B), and eyes with prior contact lens wear (Group C). Repeatability and agreement of measurements were analyzed. RESULTS: The study comprised of 214 eyes of 157 subjects. In Group A (n = 95 eyes), Group B (n = 86 eyes), and Group C (n = 33 eyes), intraclass correlation coefficient (ICC) was higher than 0.90 for all examined parameters, except for ACD readings in Group A with the REVO-NX (ICC = 0.83). Differences in ACD, TCT, and CCT were significantly different between the two devices for Groups A, B and C (p<0.05). AL measurements differed significantly in Groups A and B (p<0.05) but not in Group C (p = 0.18). Repeatability did not vary significantly between Groups A, B, or C in any parameter with both devices (p>0.05). There was poor agreement between the two devices across all parameters (p<0.05). CONCLUSIONS: Both devices demonstrated good repeatability but poor agreement across AL, ACD, CCT and TCT measurements. There was no significant difference in repeatability in virgin eyes compared to eyes with prior crosslinking or contact lens wear, however, the interchangeable use of the two devices is not recommended. Public Library of Science 2021-05-21 /pmc/articles/PMC8139453/ /pubmed/34019547 http://dx.doi.org/10.1371/journal.pone.0248659 Text en © 2021 Li et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Li, Ye
Gokul, Akilesh
McGhee, Charles
Ziaei, Mohammed
Repeatability and agreement of biometric measurements using spectral domain anterior segment optical coherence tomography and Scheimpflug tomography in keratoconus
title Repeatability and agreement of biometric measurements using spectral domain anterior segment optical coherence tomography and Scheimpflug tomography in keratoconus
title_full Repeatability and agreement of biometric measurements using spectral domain anterior segment optical coherence tomography and Scheimpflug tomography in keratoconus
title_fullStr Repeatability and agreement of biometric measurements using spectral domain anterior segment optical coherence tomography and Scheimpflug tomography in keratoconus
title_full_unstemmed Repeatability and agreement of biometric measurements using spectral domain anterior segment optical coherence tomography and Scheimpflug tomography in keratoconus
title_short Repeatability and agreement of biometric measurements using spectral domain anterior segment optical coherence tomography and Scheimpflug tomography in keratoconus
title_sort repeatability and agreement of biometric measurements using spectral domain anterior segment optical coherence tomography and scheimpflug tomography in keratoconus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139453/
https://www.ncbi.nlm.nih.gov/pubmed/34019547
http://dx.doi.org/10.1371/journal.pone.0248659
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