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Computational tools for inversion and uncertainty estimation in respirometry

In many physiological systems, real-time endogeneous and exogenous signals in living organisms provide critical information and interpretations of physiological functions; however, these signals or variables of interest are not directly accessible and must be estimated from noisy, measured signals....

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Detalles Bibliográficos
Autores principales: Cho, Taewon, Pendar, Hodjat, Chung, Julianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139500/
https://www.ncbi.nlm.nih.gov/pubmed/34019586
http://dx.doi.org/10.1371/journal.pone.0251926
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author Cho, Taewon
Pendar, Hodjat
Chung, Julianne
author_facet Cho, Taewon
Pendar, Hodjat
Chung, Julianne
author_sort Cho, Taewon
collection PubMed
description In many physiological systems, real-time endogeneous and exogenous signals in living organisms provide critical information and interpretations of physiological functions; however, these signals or variables of interest are not directly accessible and must be estimated from noisy, measured signals. In this paper, we study an inverse problem of recovering gas exchange signals of animals placed in a flow-through respirometry chamber from measured gas concentrations. For large-scale experiments (e.g., long scans with high sampling rate) that have many uncertainties (e.g., noise in the observations or an unknown impulse response function), this is a computationally challenging inverse problem. We first describe various computational tools that can be used for respirometry reconstruction and uncertainty quantification when the impulse response function is known. Then, we address the more challenging problem where the impulse response function is not known or only partially known. We describe nonlinear optimization methods for reconstruction, where both the unknown model parameters and the unknown signal are reconstructed simultaneously. Numerical experiments show the benefits and potential impacts of these methods in respirometry.
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spelling pubmed-81395002021-06-02 Computational tools for inversion and uncertainty estimation in respirometry Cho, Taewon Pendar, Hodjat Chung, Julianne PLoS One Research Article In many physiological systems, real-time endogeneous and exogenous signals in living organisms provide critical information and interpretations of physiological functions; however, these signals or variables of interest are not directly accessible and must be estimated from noisy, measured signals. In this paper, we study an inverse problem of recovering gas exchange signals of animals placed in a flow-through respirometry chamber from measured gas concentrations. For large-scale experiments (e.g., long scans with high sampling rate) that have many uncertainties (e.g., noise in the observations or an unknown impulse response function), this is a computationally challenging inverse problem. We first describe various computational tools that can be used for respirometry reconstruction and uncertainty quantification when the impulse response function is known. Then, we address the more challenging problem where the impulse response function is not known or only partially known. We describe nonlinear optimization methods for reconstruction, where both the unknown model parameters and the unknown signal are reconstructed simultaneously. Numerical experiments show the benefits and potential impacts of these methods in respirometry. Public Library of Science 2021-05-21 /pmc/articles/PMC8139500/ /pubmed/34019586 http://dx.doi.org/10.1371/journal.pone.0251926 Text en © 2021 Cho et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Cho, Taewon
Pendar, Hodjat
Chung, Julianne
Computational tools for inversion and uncertainty estimation in respirometry
title Computational tools for inversion and uncertainty estimation in respirometry
title_full Computational tools for inversion and uncertainty estimation in respirometry
title_fullStr Computational tools for inversion and uncertainty estimation in respirometry
title_full_unstemmed Computational tools for inversion and uncertainty estimation in respirometry
title_short Computational tools for inversion and uncertainty estimation in respirometry
title_sort computational tools for inversion and uncertainty estimation in respirometry
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139500/
https://www.ncbi.nlm.nih.gov/pubmed/34019586
http://dx.doi.org/10.1371/journal.pone.0251926
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